F
Fumihiko Urano
Researcher at Washington University in St. Louis
Publications - 149
Citations - 18195
Fumihiko Urano is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 48, co-authored 133 publications receiving 16108 citations. Previous affiliations of Fumihiko Urano include University of Massachusetts Boston & University of Massachusetts Amherst.
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Journal ArticleDOI
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Fumihiko Urano,Xiaozhong Wang,Anne Bertolotti,Yuhong Zhang,Peter Chung,Heather P. Harding,David Ron +6 more
TL;DR: Malfolded proteins in the endoplasmic reticulum induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs), and Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and I RE1alpha-/- fibroblasts were impaired in JNK activation by ER stress.
Journal ArticleDOI
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
Marcella Calfon,Huiqing Zeng,Fumihiko Urano,Jeffery H. Till,Stevan R. Hubbard,Heather P. Harding,Scott G. Clark,David Ron +7 more
TL;DR: It is demonstrated that mutations in either ire-1 or the transcription-factor-encoding xbp-1 gene abolished the UPR in Caenorhabditis elegans, suggesting that physiological ER load regulates a developmental decision in higher eukaryotes.
Journal ArticleDOI
Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress
Maiko Ogata,Shin-ichiro Hino,Atsushi Saito,Keisuke Morikawa,Shinichi Kondo,Soshi Kanemoto,Tomohiko Murakami,Manabu Taniguchi,Ichiro Tanii,Kazuya Yoshinaga,Sadao Shiosaka,James A. Hammarback,Fumihiko Urano,Kazunori Imaizumi +13 more
TL;DR: It is found that the autophagy system is activated as a novel signaling pathway in response to ER stress and played important roles in cell survival after ER stress.
Journal ArticleDOI
Transcriptional and Translational Control in the Mammalian Unfolded Protein Response
TL;DR: Together, these two components adapt the secretory apparatus to physiological load and protect cells from the consequences of protein malfolding.
Book ChapterDOI
Measuring ER stress and the unfolded protein response using mammalian tissue culture system
TL;DR: The current methods to measure ER stress levels, UPR activation, and subsequent pathways in mammalian cells will assist in understanding the UPR and its contribution to ER stress-related disorders such as diabetes and neurodegeneration.