F
Fumio Tashiro
Researcher at Tokyo University of Science
Publications - 61
Citations - 1600
Fumio Tashiro is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Phosphorylation & Cellular differentiation. The author has an hindex of 22, co-authored 61 publications receiving 1459 citations.
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Journal ArticleDOI
PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt
Tatsuya Kawase,Tatsuya Kawase,Rieko Ohki,Tatsuhiro Shibata,Shuichi Tsutsumi,Naoko Kamimura,Johji Inazawa,Tsutomu Ohta,Hitoshi Ichikawa,Hiroyuki Aburatani,Fumio Tashiro,Yoichi Taya,Yoichi Taya +12 more
TL;DR: PHLDA3 is identified as a p53 target gene that encodes a PH domain-only protein that competes with the PH domain of Akt for binding of membrane lipids, thereby inhibiting Akt translocation to the cellular membrane and activation.
Journal ArticleDOI
α-Zearalenol, a Major Hepatic Metabolite in Rats of Zearalenone, an Estrogenic Mycotoxin of Fusarium Species
Yoshio Ueno,Fumio Tashiro +1 more
TL;DR: All the chemical and physical data supported the view that the major metabolite, obtained by incubating zearalenone with S-9 and microsomes of rat liver in the presence of NADPH, is C-6'-alpha-hydroxylated zearAlenone (alpha-zear alenol).
Journal ArticleDOI
p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis
TL;DR: It is reported that apoptosis-enhancing nuclease (AEN) is a novel direct target gene of p53, and its expression is regulated by the phosphorylation status of p 53, and it is shown to be required for efficient DNA fragmentation in p53-dependent apoptosis.
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Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.
Jun Sunayama,Y Ando,N Itoh,Arata Tomiyama,Kaori Sakurada,Akinori Sugiyama,Dongchon Kang,Fumio Tashiro,Yukiko Gotoh,Yoshiyuki Kuchino,Yoshiyuki Kuchino,Chifumi Kitanaka +11 more
TL;DR: Yeast two-hybrid screening for Hrk-interacting proteins and isolated p32 suggest that p32 may be a key molecule that links HRk to mitochondria and is critically involved in the regulation of HrK-mediated apoptosis.
Journal ArticleDOI
A Novel Binding Factor of 14-3-3β Functions as a Transcriptional Repressor and Promotes Anchorage-independent Growth, Tumorigenicity, and Metastasis
Yuko Komiya,Nobuya Kurabe,Kumiko Katagiri,Makiko Ogawa,Akinori Sugiyama,Yasushi Kawasaki,Fumio Tashiro +6 more
TL;DR: Results indicate that FBI1 promotes sustained ERK1/2 activation through repression of MKP-1 transcription, resulting in promotion of tumorigenicity and metastasis.