Fuyuki Okamoto

TL;DR: A high SPRED1 mutation detection rate was found in NF1 mutation-negative families with an autosomal dominant phenotype of CALMs with or without freckling and no other NF1 features, and NFLS was not associated with the peripheral and central nervous system tumors seen inNF1.

TL;DR: TRAF6 is demonstrated to be critical for IFN-α/β induction in response to viral infection and intracellular double-stranded RNA, poly(I:C), and data suggest that IPS-1 requires TRAF6 and MEKK1 to activate NF-κB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons.

TL;DR: It is demonstrated that SOCS1 deletion in hepatocytes enhanced concanavalin A (ConA)–induced hepatitis and that forced expression of SOCS 1 is therapeutic in preventing hepatitis, indicating that SOCs1 plays important negative roles in fulminant hepatitis.

TL;DR: Results suggest that Spred1 negatively regulates mast cell activation, which is modulated by microRNA‐126, a miRNA located within the Egfl7 gene, and is involved in the regulation of vessel development through its role in regulating VEGF signaling.

TL;DR: Surprisingly, it is found that LTB4-BLT1 signaling restores phagocytosis in the absence of FcγRs signaling.