T
Takashi Kobayashi
Researcher at Oita University
Publications - 118
Citations - 8537
Takashi Kobayashi is an academic researcher from Oita University. The author has contributed to research in topics: Cytokine & Suppressor of cytokine signaling 1. The author has an hindex of 45, co-authored 113 publications receiving 7917 citations. Previous affiliations of Takashi Kobayashi include Keio University & University of Pennsylvania.
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Journal ArticleDOI
Distinct molecular mechanism for initiating TRAF6 signalling.
Hong Ye,Joseph R. Arron,Joseph R. Arron,Betty Lamothe,Maurizio Cirilli,Takashi Kobayashi,Nirupama K. Shevde,Deena Segal,Oki K. Dzivenu,Masha Vologodskaia,Mijung Yim,Khoi Du,Sujay Singh,J. Wesley Pike,Bryant G. Darnay,Yongwon Choi,Hao Wu +16 more
TL;DR: Crystal structures of TRAF6 are reported to identify a universal mechanism by which TRAF 6 regulates several signalling cascades in adaptive immunity, innate immunity and bone homeostasis.
Journal ArticleDOI
Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors
Marek Jutel,Takeshi Watanabe,Sven Klunker,Mübeccel Akdis,Olivier A. R. Thomet,Józef Małolepszy,Zak-Nejmark T,Ritsuko Koga,Takashi Kobayashi,Kurt Blaser,Cezmi A. Akdis +10 more
TL;DR: It is reported that histamine enhances TH1-type responses by triggering the histamine receptor type 1 (H1R), whereas bothTH1- and TH2- type responses are negatively regulated by H2R through the activation of different biochemical intracellular signals.
Journal ArticleDOI
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
Didier Marguet,Laurie L. Baggio,Takashi Kobayashi,Anne-Marie Bernard,Michel Pierres,Per Franklin Nielsen,Ulla Ribel,Takeshi Watanabe,Daniel J. Drucker,Nicolai Wagtmann +9 more
TL;DR: A critical role for CD26 is revealed in physiological glucose homeostasis, and it is established as a potential target for therapy in type II diabetes.
Journal ArticleDOI
Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt
Kenji Ichiyama,Hideyuki Yoshida,Yu Wakabayashi,Takatoshi Chinen,Kazuko Saeki,Mako Nakaya,Giichi Takaesu,Shohei Hori,Akihiko Yoshimura,Akihiko Yoshimura,Takashi Kobayashi +10 more
TL;DR: It is proposed that induction of Foxp3 is the mechanism for the suppression of Th17 and polarization into inducible Treg.
Journal ArticleDOI
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis.
Nacksung Kim,Yuho Kadono,Masamichi Takami,Junwon Lee,Seoung Hoon Lee,Fumihiko Okada,Jung Ha Kim,Takashi Kobayashi,Paul R. Odgren,Hiroyasu Nakano,Wen-Chen Yeh,Sun-Kyeong Lee,Joseph A. Lorenzo,Yongwon Choi +13 more
TL;DR: Surprisingly, it is shown that hematopoietic precursors from TRANCE-, RANK-, or TRAF6-null mice can become osteoclasts in vitro when they are stimulated with TNF-α in the presence of cofactors such as TGF-β.