G
G.A.T. Laranja
Researcher at Rio de Janeiro State University
Publications - 12
Citations - 569
G.A.T. Laranja is an academic researcher from Rio de Janeiro State University. The author has contributed to research in topics: Heme & Trypanosoma cruzi. The author has an hindex of 11, co-authored 12 publications receiving 527 citations.
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Journal ArticleDOI
Toxicological evaluation by in vitro and in vivo assays of an aqueous extract prepared from Echinodorus macrophyllus leaves
Leonardo da Costa Lopes,Franco Albano,G.A.T. Laranja,Luciano Marques Alves,Luis Fernando Martins e Silva,Gabriele Poubel de Souza,Isabela de Magalhães Araujo,José Firmino Nogueira-Neto,Israel Felzenszwalb,Karla Kovary +9 more
TL;DR: Exposure dose of 23 mg/kg, equivalent to the daily dose recommended to humans, did not revealed any genotoxic effect and hence this herb seems to be safe to human organism.
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Proliferation and differentiation of Trypanosoma cruzi inside its vector have a new trigger: redox status.
Natália Pereira de Almeida Nogueira,Francis M. S. Saraiva,Pedro Elias Sultano,Paula R. B. B. Cunha,G.A.T. Laranja,Graça Justo,Kátia Costa de Carvalho Sabino,Marsen Garcia Pinto Coelho,Ana Rossini,Georgia C. Atella,Marcia Cristina Paes +10 more
TL;DR: A shift in the triatomine gut microenvironment caused by the redox status may also influence T. cruzi biology inside the vector and this insight defines a key role for redox metabolism in governing the parasitic life cycle.
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Heme requirement and intracellular trafficking in Trypanosoma cruzi epimastigotes.
Flávio Alves Lara,Celso Sant’Anna,D. Lemos,G.A.T. Laranja,Marsen Garcia Pinto Coelho,I. Reis Salles,A. Michel,Pedro L. Oliveira,Narcisa L. Cunha-e-Silva,Didier Salmon,Marcia Cristina Paes +10 more
TL;DR: It is concluded that a P-glycoprotein homologue transporter is probably involved in heme transport through the plasma membrane because heme internalization proceeded much faster than that observed by hemoglobin-rhodamine.
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Biochemical behaviour of norbixin during in vitro DNA damage induced by reactive oxygen species
Karla Kovary,Tatiana S. Louvain,Maria Cristina da Costa e Silva,Franco Albano,Bárbara Balzana Mendes Pires,G.A.T. Laranja,Celso Luiz Salgueiro Lage,Israel Felzenszwalb +7 more
TL;DR: In this article, the cell-free scavenger activity of norbixin was evaluated using plasmid DNA as target molecule and Sn 2+ or Fe 2+ as oxidant.
Journal ArticleDOI
Anti- Trypanosoma cruzi activity of Pterodon pubescens seed oil: geranylgeraniol as the major bioactive component
Rubem Figueiredo Sadok Menna-Barreto,G.A.T. Laranja,Maria Cristina da Costa e Silva,Marsen Garcia Pinto Coelho,Marcia Cristina Paes,M. M. Oliveira,S. L. De Castro +6 more
TL;DR: Transmission electron microscopy and flow cytometry analysis and ultrastructural images of the endoplasmic reticulum profiles, myelin-like figures, and concentric membranous arrangements inside damaged mitochondrion are suggestive of an autophagic pathway leading to parasite death, and further studies are needed to disclose the trypanocidal action of GG-OH.