S. L. De Castro

TL;DR: Four compounds isolated from Brazilian propolis induced a relaxant effect similar to propolis extract against Trypanosoma cruzi and the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus faecalis.

TL;DR: The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.

TL;DR: Ulastructural, flow cytometry, and biochemical studies suggest that naphthoimidazoles interferes with the energetic metabolism and induces DNA fragmentation in parasite death.

TL;DR: Evidence point to autophagy as the predominant phenotype induced by the naphthoimidazoles, however, there are other pathways occurring concomitantly with variable intensities, justifying the need to detail the molecular features involved.

TL;DR: Different formulations of propolis were administered to experimentally Trypanosoma cruzi-infected mice and the parasitemia kinetics and survival rate were monitored, finding that oral administration of ethanolic extracts did not interfere with both parameters.