G
G.C.F. van Duijnhoven
Researcher at Philips
Publications - 8
Citations - 5336
G.C.F. van Duijnhoven is an academic researcher from Philips. The author has contributed to research in topics: DC-SIGN & Dendritic cell. The author has an hindex of 7, co-authored 8 publications receiving 5195 citations.
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Journal ArticleDOI
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
Teunis B.H. Geijtenbeek,Douglas S. Kwon,Ruurd Torensma,S.J. van Vliet,G.C.F. van Duijnhoven,J. Middel,I.L.M.H.A. Cornelissen,H.S.L.M. Nottet,Vineet N. KewalRamani,Dan R. Littman,Carl G. Figdor,Y. van Kooyk +11 more
TL;DR: It is proposed that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
Journal ArticleDOI
Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses
Teunis B.H. Geijtenbeek,Ruurd Torensma,S.J. van Vliet,G.C.F. van Duijnhoven,Gosse Jan Adema,Y. van Kooyk,Carl G. Figdor +6 more
TL;DR: It is demonstrated that ICAM-3 expressed by resting T cells is important in this first contact with dendritic cells, and it is predicted that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone.
Journal ArticleDOI
DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking
T.B.H. (Theo) Geijtenbeek,Daniëlle J. E. B. Krooshoop,D.A. Bleijs,S.J. van Vliet,G.C.F. van Duijnhoven,Valentin Grabovsky,Ronen Alon,Carl G. Figdor,Y. van Kooyk +8 more
TL;DR: It is shown that DC-SIGN, a DC-specific C-type lectin, supports tethering and rolling of DC-sign–positive cells on the vascular ligand ICAM-2 under shear flow, a prerequisite for emigration from blood.
Journal Article
DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking
T.B.H. (Theo) Geijtenbeek,Daniëlle J. E. B. Krooshoop,D.A. Bleijs,S.J. van Vliet,G.C.F. van Duijnhoven,V. Grobovsky,Ronen Alon,Carl G. Figdor,Y. van Kooyk +8 more
Journal ArticleDOI
DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review.
TL;DR: A DC-specific C-type lectin that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120 is described that promotes efficient infection in trans of cells that express CD4 and chemokine receptors.