Ruurd Torensma

TL;DR: It is proposed that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.

TL;DR: It is demonstrated that ICAM-3 expressed by resting T cells is important in this first contact with dendritic cells, and it is predicted that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone.

TL;DR: How direct targeting of antigens to DC surface receptors in vivo might replace laborious and expensive ex vivo culturing, and facilitate large-scale application of DC-based vaccination therapies is discussed.

TL;DR: It is demonstrated that cytokine production by human mononuclear cells or murine macrophages was markedly reduced when stimulated by C. albicans mutants defective in mannosylation and recognition of C.Albicans by monocytes/macrophages is mediated by 3 recognition systems of differing importance, each of which senses specific layers of the C. Albicans cell wall.

TL;DR: The appearance of cytomegalovirus antigen positive blood leucocytes (CMV antigenaemia) was investigated in 52 renal transplant recipients during the first three months after transplantation and results were related to virus isolation from buffy coats, serology with a sensitive enzyme‐linked immunosorbent assay (ELISA), and clinical symptoms of CMV disease.