G
G. N. J. Tytgat
Researcher at University of Amsterdam
Publications - 297
Citations - 18284
G. N. J. Tytgat is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Helicobacter pylori & Carcinoma. The author has an hindex of 68, co-authored 297 publications receiving 17845 citations.
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Journal ArticleDOI
Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2).
H. M. Van Dullemen,S. J. H. Van Deventer,Daan W. Hommes,H. A. Bijl,Jeroen M. Jansen,G. N. J. Tytgat,J. Woody +6 more
TL;DR: The hypothesis that TNF is of major importance in the pathogenesis of Crohn's disease is supported, and treatment with cA2 was safe and may be useful in patients with Crohn’s disease that is unresponsive to steroid treatment.
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Randomised trial of self-expanding metal stents versus polyethylene stents for distal malignant biliary obstruction.
TL;DR: Self-expanding metal stents have a longer patency than polyethylene stents and offer adequate palliation in patients with irresectable malignant distal bile-duct obstruction and incremental cost-effectiveness analysis showed that initial placement of a metal stent results in a 28% decrease of endoscopic procedures.
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Barrett's esophagus: development of dysplasia and adenocarcinoma.
TL;DR: The results of this study support the need for a long-term clinical, endoscopic, and histologic follow-up program in patients with Barrett's esophagus with an incidence of carcinoma of 1 in 52 patient-years, a 125-fold increase compared with the general Dutch population.
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Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection.
L. A. Noach,N. B. Bosma,Jeroen M. Jansen,Frans J. Hoek,S. J. H. Van Deventer,G. N. J. Tytgat +5 more
TL;DR: A strong correlation was found between the production of IL-1 beta and IL-8 and the biologic effects of these cytokines may explain the conspicuous recruitment, influx, and activation of neutrophils in the gastric mucosa during H. pylori infection.
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Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000.
M E van Leerdam,E. M. Vreeburg,E. A. J. Rauws,A. A.M. Geraedts,Jan G.P. Tijssen,Johannes B. Reitsma,G. N. J. Tytgat +6 more
TL;DR: In this paper, the authors examined recent time trends in incidence and outcome of upper GI bleeding and found that the incidence was higher among patients of more advanced age, increasing age, presence of severe and life-threatening comorbidity, and rebleeding were associated with higher mortality.