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Albert K. Groen
Researcher at University of Amsterdam
Publications - 323
Citations - 23983
Albert K. Groen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Cholesterol & Reverse cholesterol transport. The author has an hindex of 73, co-authored 308 publications receiving 20399 citations. Previous affiliations of Albert K. Groen include University Medical Center Groningen & University of Groningen.
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Journal ArticleDOI
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
Gijs den Besten,Karen van Eunen,Albert K. Groen,Koen Venema,Dirk-Jan Reijngoud,Barbara M. Bakker +5 more
TL;DR: This review summarizes the role of SCFAs in host energy metabolism, starting from the production by the gut microbiota to the uptake by the host and ending with the effects on host metabolism.
Journal ArticleDOI
Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome
A. Vrieze,Els van Nood,Frits Holleman,Jarkko Salojärvi,Ruud S. Kootte,Joep F. Bartelsman,Geesje M. Dallinga-Thie,Mariëtte T. Ackermans,Mireille J. Serlie,Raish Oozeer,Muriel Derrien,Anne Druesne,Johan E. T. van Hylckama Vlieg,Vincent W. Bloks,Albert K. Groen,Hans G.H.J. Heilig,Erwin G. Zoetendal,Erik S.G. Stroes,Willem M. de Vos,Willem M. de Vos,Joost B. L. Hoekstra,Max Nieuwdorp +21 more
TL;DR: Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased along with levels of butyrate-producing intestinal microbiota, and intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans.
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Randomised trial of self-expanding metal stents versus polyethylene stents for distal malignant biliary obstruction.
TL;DR: Self-expanding metal stents have a longer patency than polyethylene stents and offer adequate palliation in patients with irresectable malignant distal bile-duct obstruction and incremental cost-effectiveness analysis showed that initial placement of a metal stent results in a 28% decrease of endoscopic procedures.
Journal ArticleDOI
Short-Chain Fatty Acids protect against High-Fat Diet-Induced Obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation
Gijs den Besten,Aycha Bleeker,Albert Gerding,Karen van Eunen,Rick Havinga,Theo H. van Dijk,Maaike H. Oosterveer,Johan W. Jonker,Albert K. Groen,Dirk-Jan Reijngoud,Barbara M. Bakker +10 more
TL;DR: It is shown that dietary SCFAs induce a peroxisome proliferator–activated receptor-γ (PPARγ)–dependent switch from lipid synthesis to utilization, which demonstrates that adipose and hepatic PPARγ are critical mediators of the beneficial effects ofSCFAs on the metabolic syndrome.
Journal ArticleDOI
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
Ruud S. Kootte,Evgeni Levin,Jarkko Salojärvi,Loek P. Smits,Annick V. Hartstra,Shanti D. Udayappan,Gerben D. A. Hermes,Kristien E. C. Bouter,Annefleur M. Koopen,Jens J. Holst,Filip K. Knop,Ellen E. Blaak,Jing Hua Zhao,Hauke Smidt,Amy C. Harms,Thomas Hankemeijer,Jacques J. Bergman,Hans A. Romijn,Frank G. Schaap,Steven W.M. Olde Damink,Mariëtte T. Ackermans,Geesje M. Dallinga-Thie,Erwin G. Zoetendal,Willem M. de Vos,Mireille J. Serlie,Erik S.G. Stroes,Albert K. Groen,Max Nieuwdorp +27 more
TL;DR: The beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.