D
Daan W. Hommes
Researcher at University of California, Los Angeles
Publications - 159
Citations - 13260
Daan W. Hommes is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 52, co-authored 154 publications receiving 12531 citations. Previous affiliations of Daan W. Hommes include Leiden University & UCLA Health.
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Journal ArticleDOI
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management
Axel Dignass,G. Van Assche,James O. Lindsay,Marc Lémann,Johan D. Söderholm,Jean-Frederic Colombel,Silvio Danese,André D'Hoore,Miquel A. Gassull,Fernando Gomollón,Daan W. Hommes,Pierre Michetti,Colm O'Morain,Tom Øresland,Alastair Windsor,Eduard F. Stange,Simon Travis +16 more
TL;DR: This paper is the second in a series of three publications relating to the European evidence-based consensus on the diagnosis and management of Crohn's disease and concerns the management of active disease, maintenance of medically induced remission and surgery.
Journal ArticleDOI
Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2).
H. M. Van Dullemen,S. J. H. Van Deventer,Daan W. Hommes,H. A. Bijl,Jeroen M. Jansen,G. N. J. Tytgat,J. Woody +6 more
TL;DR: The hypothesis that TNF is of major importance in the pathogenesis of Crohn's disease is supported, and treatment with cA2 was safe and may be useful in patients with Crohn’s disease that is unresponsive to steroid treatment.
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Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn’s disease
Jan M. H. van den Brande,Henri Braat,Gijs R. van den Brink,Henri H. Versteeg,Christiaan A Bauer,Inge Hoedemaeker,Catherine van Montfrans,Daan W. Hommes,Maikel P. Peppelenbosch,Sander J. H. van Deventer +9 more
TL;DR: Only infliximab was able to bind to PBL and lamina propria T cells and subsequently to induce apoptosis of activated lymphocytes, which may provide a biological basis for the difference in efficacy of the 2 TNF-alpha-neutralizing drugs.
Journal ArticleDOI
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Dermot P.B. McGovern,Agnes Gardet,Leif Törkvist,Philippe Goyette,Jonah Essers,Kent D. Taylor,Benjamin M. Neale,Rick Twee-Hee Ong,Caroline Lagacé,Chun Li,Todd Green,Christine Stevens,Claudine Beauchamp,Phillip Fleshner,Marie Carlson,Mauro D'Amato,Jonas Halfvarson,Martin L. Hibberd,Mikael Lördal,Leonid Padyukov,Angelo Andriulli,Elisabetta Colombo,Anna Latiano,Orazio Palmieri,Edmond Jean Bernard,Colette Deslandres,Daan W. Hommes,Dirk J. de Jong,Pieter C. F. Stokkers,Rinse K. Weersma,Yashoda Sharma,Mark S. Silverberg,Judy H. Cho,Jing Wu,Jing Wu,Kathryn Roeder,Steven R. Brant,L Phillip Schumm,Richard H. Duerr,Marla Dubinsky,Nicole L. Glazer,Talin Haritunians,Andrew Ippoliti,Gil Y. Melmed,David S. Siscovick,Eric A. Vasiliauskas,Stephan R. Targan,Vito Annese,Cisca Wijmenga,Sven Pettersson,Jerome I. Rotter,Jerome I. Rotter,Ramnik J. Xavier,Mark J. Daly,John D. Rioux,Mark Seielstad +55 more
TL;DR: Two distinct genome-wide association studies of ulcerative colitis are presented and their joint analysis with a previously published scan shows that roughly half of the known Crohn's disease associations are shared with ulceratives colitis, thereby providing insight into disease pathogenesis.
Journal ArticleDOI
European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis
Eduard F. Stange,Simon Travis,Severine Vermeire,Walter Reinisch,K. Geboes,A. Barakauskiene,R. Feakins,Jean-François Fléjou,Hans H Herfarth,Daan W. Hommes,Limas Kupčinskas,Peter L. Lakatos,Gerassimos J. Mantzaris,Stefan Schreiber,Vincenzo Villanacci,Bryan F. Warren +15 more
TL;DR: The aim of the Consensus is to promote a European perspective on the management of ulcerative colitis (UC) and its dilemmas and to avoid duplication of effort in the future.