G
G. Somlo
Researcher at Beckman Research Institute
Publications - 31
Citations - 1963
G. Somlo is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 11, co-authored 31 publications receiving 1644 citations. Previous affiliations of G. Somlo include Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis
Weiying Zhou,Weiying Zhou,Miranda Y. Fong,Yongfen Min,G. Somlo,Liang Liu,Liang Liu,Melanie R. Palomares,Yang Yu,Yang Yu,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Andrew R. Chin,Yun Yen,Yafan Wang,Eric G. Marcusson,Peiguo Chu,Jun Wu,Xiwei Wu,Arthur X. Li,Zhuo Li,Hanlin Gao,Xiubao Ren,Mark Boldin,Pengnian Charles Lin,Shizhen Emily Wang +25 more
TL;DR: It is shown that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1.
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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
Heehyoung Lee,Jiehui Deng,Maciej Kujawski,Chunmei Yang,Yong-Yong Liu,Andreas Herrmann,Marcin Kortylewski,David Horne,G. Somlo,Stephen J. Forman,Richard Jove,Hua Yu +11 more
TL;DR: It is shown that STAT3-induced S1pr1 expression, as well as the S1P-S1PR1 pathway reciprocal regulation of STAT3 activity, is a major positive feedback loop for persistent STAT3 activation in cancer cells and the tumor microenvironment and for malignant progression.
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A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis
Ferenc A. Scheeren,Angera H. Kuo,Linda J. van Weele,Shang Cai,Iris E. Glykofridis,Shaheen S. Sikandar,Maider Zabala,Dalong Qian,Jessica Lam,Darius M. Johnston,Jens Peter Volkmer,Debashis Sahoo,Matt van de Rijn,Frederick M. Dirbas,G. Somlo,Tomer Kalisky,Michael E. Rothenberg,Stephen R. Quake,Michael F. Clarke +18 more
TL;DR: A role for cell-intrinsic toll-like receptor-2 (TLR2; which is involved in inflammatory response) signalling in normal intestinal and mammary epithelial cells and oncogenesis is described and inhibitors of the TLR2 pathway merit investigation as possible therapeutic and chemoprevention agents.
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Inflammatory Biomarkers, Comorbidity, and Neurocognition in Women With Newly Diagnosed Breast Cancer.
Sunita K. Patel,Andrew L. Wong,F. Lennie Wong,Elizabeth C. Breen,Arti Hurria,Mackenzie Smith,Christine Kinjo,I. Benjamin Paz,Laura Kruper,G. Somlo,Joanne E. Mortimer,Melanie R. Palomares,Michael R. Irwin,Smita Bhatia +13 more
TL;DR: An association of TNF with memory, previously reported in patients after exposure to chemotherapy, was found prior to initiation of any treatment, including surgery, as sTNF-RII was not higher in cancer patients relative to control participants.
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In vivo purging with high-dose cytarabine followed by high-dose chemoradiotherapy and reinfusion of unpurged bone marrow for adult acute myelogenous leukemia in first complete remission.
Anthony S. Stein,M R O'Donnell,A Chai,G M Schmidt,A P Nademanee,Pablo M. Parker,Eileen P. Smith,David S. Snyder,Arturo Molina,DE Stepan,Ricardo Spielberger,G. Somlo,Kim Margolin,Nayana Vora,J A Lipsett,Jennifer A. Lee,Joyce C. Niland,S.J. Forman +17 more
TL;DR: This approach offers a relatively high DFS rate to adult patients with AML in first CR and the results of this study are similar to those achieved with allogeneic BMT.