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Andrew R. Chin
Researcher at University of California, San Diego
Publications - 11
Citations - 3039
Andrew R. Chin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 10, co-authored 11 publications receiving 2312 citations. Previous affiliations of Andrew R. Chin include City of Hope National Medical Center & Beckman Research Institute.
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Journal ArticleDOI
Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis
Weiying Zhou,Weiying Zhou,Miranda Y. Fong,Yongfen Min,G. Somlo,Liang Liu,Liang Liu,Melanie R. Palomares,Yang Yu,Yang Yu,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Andrew R. Chin,Yun Yen,Yafan Wang,Eric G. Marcusson,Peiguo Chu,Jun Wu,Xiwei Wu,Arthur X. Li,Zhuo Li,Hanlin Gao,Xiubao Ren,Mark Boldin,Pengnian Charles Lin,Shizhen Emily Wang +25 more
TL;DR: It is shown that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1.
Journal ArticleDOI
Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
Miranda Y. Fong,Weiying Zhou,Liang Liu,Aileen Y. Alontaga,Manasa Chandra,Jonathan Ashby,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Shasha Li,Andrew R. Chin,George Somlo,Melanie R. Palomares,Zhuo Li,Jacob R. Tremblay,Akihiro Tsuyada,Guoqiang Sun,Michael A. Reid,Xiwei Wu,Piotr Swiderski,Xiubao Ren,Yanhong Shi,Mei Kong,Wenwan Zhong,Yuan Chen,Shizhen Emily Wang +24 more
TL;DR: It is demonstrated that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression.
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Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB
Amy Y. M. Chow,Weiying Zhou,Weiying Zhou,Liang Liu,Liang Liu,Miranda Y. Fong,Jackson Champer,Desiree Van Haute,Andrew R. Chin,Xiubao Ren,Bogdan Gabriel Gugiu,Zhipeng Meng,Wendong Huang,Vu N. Ngo,Marcin Kortylewski,Shizhen Emily Wang +15 more
TL;DR: A novel mechanism used by breast cancer cells to induce pro-inflammatory activity of distant macrophages through circulating exosomal vesicles secreted during cancer progression is highlighted.
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Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.
Wei Yan,Xiwei Wu,Weiying Zhou,Weiying Zhou,Miranda Y. Fong,Miranda Y. Fong,Minghui Cao,Juan Liu,Xiaojing Liu,Chih Hong Chen,Oluwole Fadare,Donald P. Pizzo,Jiawen Wu,Liang Liu,Xuxiang Liu,Andrew R. Chin,Andrew R. Chin,Xiubao Ren,Yuan Chen,Jason W. Locasale,Shizhen Emily Wang +20 more
TL;DR: It is shown that exosomal miR-105 derived from cancer cells confers metabolic plasticity in recipient cancer-associated fibroblasts to adapt to nutrient-replete and -deplete conditions, thereby sustaining tumour growth.
Journal ArticleDOI
Cross-kingdom inhibition of breast cancer growth by plant miR159
Andrew R. Chin,Miranda Y. Fong,George Somlo,Jun Wu,Piotr Swiderski,Xiwei Wu,Shizhen Emily Wang +6 more
TL;DR: These results demonstrate for the first time that a plant miRNA can inhibit cancer growth in mammals.