Gabriel Arrambide

TL;DR: In the search for new therapeutic tools against Chagas' disease (American Trypanosomiasis) four novel mixed-ligand vanadyl complexes, including a bidentate polypyridyl DNA intercalator and a tridentate salycylaldehyde semicarbazone derivative as ligands were synthesized, characterized by a combination of techniques and in vitro evaluated.

TL;DR: The anti-trypanosomal activity of these vanadium complexes could be explained on the basis of their lipophilicity and the electronic characteristics of the quinoxaline substituents.

TL;DR: V(V)-Salsem displayed cytotoxic effects on osteoblasts in culture through the production of free radicals and the activation of ERK cascade and these mechanisms triggered the apoptotic events that conveyed to cell death.

TL;DR: It is considered that [VO(NH(2)O)(2)(met)] is a good candidate to be tested in in vivo models as a potential antitumoral agent and shows an important role for oxidative stress in the toxicity mechanism of action.

TL;DR: A series of mixed ligand oxovanadium(V) complexes of the type [VO(NH2O)2(aa)], containing the hydroxylamido ligand and simple amino acids, were prepared and characterized as discussed by the authors.