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Isabel Tomaz
Researcher at Instituto Superior Técnico
Publications - 25
Citations - 1216
Isabel Tomaz is an academic researcher from Instituto Superior Técnico. The author has contributed to research in topics: Circular dichroism & Salicylaldehyde. The author has an hindex of 19, co-authored 25 publications receiving 1152 citations. Previous affiliations of Isabel Tomaz include Technical University of Lisbon & University of Coimbra.
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Journal ArticleDOI
Transport of therapeutic vanadium and ruthenium complexes by blood plasma components.
J. Costa Pessoa,Isabel Tomaz +1 more
TL;DR: It is concluded that vanadium compounds are mainly transported in blood by transferrin, but that no study has properly addressed the influence of albumin and transferrin in the vanadium uptake by cells.
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Biospeciation of various antidiabetic VIVO compounds in serum
Tamás Jakusch,Dominik Hollender,Éva A. Enyedy,Cristina Sánchez González,Maria Montes-Bayón,Alfredo Sanz-Medel,João Costa Pessoa,Isabel Tomaz,Tamás Kiss +8 more
TL;DR: In this article, the interactions of various insulin mimetic oxovanadium(IV) compounds with serum proteins were studied in model systems and in ex vivo samples. And the results were confirmed by HPLC-ICP-MS (liquid chromatography-inductively coupled plasma spectroscopy mass spectrometry) measurements.
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Design of vanadium mixed-ligand complexes as potential anti-protozoa agents.
Julio Benítez,Lucía Guggeri,Isabel Tomaz,Isabel Tomaz,Gabriel Arrambide,Maribel Navarro,João Costa Pessoa,Beatriz Garat,Dinorah Gambino +8 more
TL;DR: In the search for new therapeutic tools against Chagas' disease (American Trypanosomiasis) four novel mixed-ligand vanadyl complexes, including a bidentate polypyridyl DNA intercalator and a tridentate salycylaldehyde semicarbazone derivative as ligands were synthesized, characterized by a combination of techniques and in vitro evaluated.
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Preparation and characterisation of new oxovanadium(iv) schiff base complexes derived from amino acids and aromatic o-hydroxyaldehydes
J. Costa Pessoa,Isabel Cavaco,Isabel Correia,Maria Teresa Duarte,Robert D. Gillard,Rui Henriques,F.J. Higes,Catarina Madeira,Isabel Tomaz +8 more
TL;DR: A range of mostly new oxovanadium(IV) complexes are described in this paper, which contain coordinated Schiff bases, made from natural amino acids (glycine, alanine, valine, leucine, isoleucine and methionine, phenylalanine, threonine, aspartic acid, and histidine) and salicylaldehyde or such derivatives as 3-, 4-, or 5-methoxy-salicyl-aldehyde.
Journal ArticleDOI
A novel vanadyl complex with a polypyridyl DNA intercalator as ligand: a potential anti-protozoa and anti-tumor agent.
Julio Benítez,Lucía Guggeri,Isabel Tomaz,Isabel Tomaz,João Costa Pessoa,Virtudes Moreno,Julia Lorenzo,Francesc X. Avilés,Beatriz Garat,Dinorah Gambino +9 more
TL;DR: The vanadyl complex exhibited excellent in vitro anti-tumor activity against leukemia comparable to that of cisplatin, inducing cell death by apoptosis with IC(50) values in the micromolar range.