Gail Wagoner

TL;DR: The data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically TH17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases.

TL;DR: It is concluded that BDNF and GDNF released from exercising muscle may be involved in exercise‐induced plasticity of the spinal cord and the data suggest that the lumbar spinal cord undergoes time‐dependent changes that temporarily impede the ability of the muscle to respond to exercise.

TL;DR: Data indicate an age- and region-specific susceptibility to EtOH regulation of neuroinflammatory and addiction-related molecules as well as astrocyte phenotype.

TL;DR: It is demonstrated that the LXR agonist T0901317 suppressed IL‐17A expression from splenocytes derived from Vα2.3/Vβ8.2 TCR transgenic mice and from MOG35–55‐immunized C57BL/6 mice, and that the development of EAE was suppressed in an experimental paradigm involving treatment of established EAE.

TL;DR: Through its ability to attenuate excessive inflammation and accelerate abscess encapsulation, ciglitazone may effectively sequester brain abscesses and limit bacterial dissemination.