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Yongjun Wang
Researcher at Scripps Research Institute
Publications - 38
Citations - 4642
Yongjun Wang is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Nuclear receptor & Receptor. The author has an hindex of 26, co-authored 38 publications receiving 4128 citations. Previous affiliations of Yongjun Wang include Chinese Academy of Sciences & Nanjing Agricultural University.
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Journal ArticleDOI
Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Vikas Chandra,Pengxiang Huang,Yoshitomo Hamuro,Srilatha Raghuram,Yongjun Wang,Thomas P. Burris,Fraydoon Rastinejad +6 more
TL;DR: Structures of intact PPAR-γ and RXR-α are presented as a heterodimer bound to DNA, ligands and coactivator peptides, allowing the ligand-binding domain (LBD) of PPar-γ to contact multiple domains in both proteins.
Journal ArticleDOI
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
Laura A. Solt,Yongjun Wang,Subhashis Banerjee,Travis G Hughes,Douglas J. Kojetin,Thomas Lundasen,Youseung Shin,J. J. Liu,Michael D. Cameron,Romain Noel,Seung Hee Yoo,Joseph S. Takahashi,Andrew A. Butler,Theodore M. Kamenecka,Thomas P. Burris +14 more
TL;DR: Treatment of diet-induced obese mice with a REV-ERB agonist decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia, indicating that synthetic REV -ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
Journal ArticleDOI
Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand
Laura A. Solt,P. Naresh Kumar,Philippe Nuhant,Yongjun Wang,Janelle L. Lauer,J. J. Liu,Monica A. Istrate,Theodore M. Kamenecka,William R. Roush,Dusica Vidovic,Dusica Vidovic,Stephan C. Schürer,Stephan C. Schürer,Jihong Xu,Gail Wagoner,Paul D. Drew,Patrick R. Griffin,Thomas P. Burris +17 more
TL;DR: The data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically TH17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases.
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QTL mapping of ten agronomic traits on the soybean ( Glycine max L. Merr.) genetic map and their association with EST markers.
Weiwei Zhang,Yongjun Wang,Guang-Zuo Luo,J.-S. Zhang,C.-Y. He,Xun-Zong Wu,Junyi Gai,Shuiliang Chen +7 more
TL;DR: A set of 184 recombinant inbred lines (RILs) derived from soybean vars was used to construct a genetic linkage map, and the two parents exhibit contrasting characteristics for most of the traits that were mapped.
Journal ArticleDOI
The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor-α/γ Inverse Agonist
Naresh Kumar,Laura A. Solt,Juliana J. Conkright,Yongjun Wang,Monica A. Istrate,Scott A. Busby,Ruben D. Garcia-Ordonez,Thomas P. Burris,Patrick R. Griffin +8 more
TL;DR: The results demonstrate that small molecules can be used to target the RORs for therapeutic intervention in metabolic and immune disorders and an excellent starting point for the development of ROR selective modulators.