J
Jihong Xu
Researcher at University of Arkansas for Medical Sciences
Publications - 22
Citations - 1638
Jihong Xu is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Peroxisome proliferator-activated receptor. The author has an hindex of 16, co-authored 18 publications receiving 1524 citations.
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Journal ArticleDOI
Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand
Laura A. Solt,P. Naresh Kumar,Philippe Nuhant,Yongjun Wang,Janelle L. Lauer,J. J. Liu,Monica A. Istrate,Theodore M. Kamenecka,William R. Roush,Dusica Vidovic,Dusica Vidovic,Stephan C. Schürer,Stephan C. Schürer,Jihong Xu,Gail Wagoner,Paul D. Drew,Patrick R. Griffin,Thomas P. Burris +17 more
TL;DR: The data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically TH17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases.
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Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: Implications for multiple sclerosis
TL;DR: The results show that TZDs and 15d-PGJ(2) are effective in inhibiting production of nitric oxide, the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and the chemokine MCP-1 from microglia and astrocytes.
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Agonists for the peroxisome proliferator-activated receptor-α and the retinoid X receptor inhibit inflammatory responses of microglia
TL;DR: The results raise the possibility that PPAR‐α and RXR agonists might have benefit as a therapy in MS, where activated microglia are believed to contribute to disease pathology.
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9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes.
Jihong Xu,Paul D. Drew +1 more
TL;DR: The results suggest that RA modulates EAE, at least in part, by suppressing the production of NO and specific inflammatory cytokines from activated glia and suggests that RA might be effective in the treatment of MS.
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Effects of Ethanol on Immune Response in the Brain: Region Specific Changes in Adolescent versus Adult Mice
Cynthia J.M. Kane,Kevin D. Phelan,James C. Douglas,Gail Wagoner,Jennifer W. Johnson,Jihong Xu,Patrick S. Phelan,Paul D. Drew +7 more
TL;DR: Data indicate an age- and region-specific susceptibility to EtOH regulation of neuroinflammatory and addiction-related molecules as well as astrocyte phenotype.