J
J. J. Liu
Researcher at Scripps Research Institute
Publications - 4
Citations - 2133
J. J. Liu is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Semisynthesis & Taxus brevifolia. The author has an hindex of 4, co-authored 4 publications receiving 1906 citations.
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Journal ArticleDOI
Total synthesis of taxol
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Zhen Yang,J. J. Liu,H. Ueno,P. G. Nantermet,R. K. Guy,Christopher F. Claiborne,J. Renaud,Elias A. Couladouros,K. Paulvannan,Erik J. Sorensen,Erik J. Sorensen +12 more
TL;DR: The total synthesis of taxol is reported by a convergent strategy, which opens a chemical pathway for the production of both the natural product itself and a variety of designed taxoids.
Journal ArticleDOI
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
Laura A. Solt,Yongjun Wang,Subhashis Banerjee,Travis G Hughes,Douglas J. Kojetin,Thomas Lundasen,Youseung Shin,J. J. Liu,Michael D. Cameron,Romain Noel,Seung Hee Yoo,Joseph S. Takahashi,Andrew A. Butler,Theodore M. Kamenecka,Thomas P. Burris +14 more
TL;DR: Treatment of diet-induced obese mice with a REV-ERB agonist decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia, indicating that synthetic REV -ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
Journal ArticleDOI
Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand
Laura A. Solt,P. Naresh Kumar,Philippe Nuhant,Yongjun Wang,Janelle L. Lauer,J. J. Liu,Monica A. Istrate,Theodore M. Kamenecka,William R. Roush,Dusica Vidovic,Dusica Vidovic,Stephan C. Schürer,Stephan C. Schürer,Jihong Xu,Gail Wagoner,Paul D. Drew,Patrick R. Griffin,Thomas P. Burris +17 more
TL;DR: The data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically TH17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases.
Journal ArticleDOI
Total synthesis of taxol.
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Zhen Yang,J. J. Liu,H. Ueno,P. G. Nantermet,R. K. Guy,Christopher F. Claiborne,J. Renaud,Elias A. Couladouros,K. Paulvannan,Erik J. Sorensen,Erik J. Sorensen +12 more
TL;DR: Taxol, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients as mentioned in this paper.