Ganesh Shankarling

TL;DR: DDX17 has dual roles in the recognition of stem loops: in the nucleus for endogenous microRNA (miRNA) biogenesis and in the cytoplasm for surveillance against structured non-self-elements.

TL;DR: hnRNP L represses CD45 exon 4 by recruiting hnRNP A1 to a sequence upstream of the 5' splice site and this work demonstrates that conformational perturbations within the spliceosome are a naturally occurring and generalizable mechanism for controlling alternative splicing decisions.

TL;DR: This study uses cross-linking and immunoprecipitation followed by high-throughput sequencing to identify the RNA binding sites of hnRNP L within the transcriptomes of human CD4+ and cultured Jurkat T cells and finds that hn RNP L binds preferentially to transcripts encoding proteins involved in RNA processing and in Wnt and T cell receptor (TCR) signaling.

TL;DR: It is proposed that the location of CELF2 binding around an exon is a primary predictor of Celf2 function in a broad range of cellular contexts and is sufficient to explain the bi-directional activity of CELF2 on 2 T cell targets recently reported.

TL;DR: This is the first report of a family of splice variants encoding a key polyadenylation protein that is expressed in a nervous system-specific manner and it is proposed that βCstF-64 contributes to proteomic diversity by regulating alternative polyadenYLation of neural mRNAs.