G
Gang Bao
Researcher at Rice University
Publications - 265
Citations - 32915
Gang Bao is an academic researcher from Rice University. The author has contributed to research in topics: Genome editing & Molecular beacon. The author has an hindex of 77, co-authored 246 publications receiving 28096 citations. Previous affiliations of Gang Bao include Sun Yat-sen University & Johns Hopkins University.
Papers
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Journal ArticleDOI
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu,David A. Scott,David A. Scott,Joshua A. Weinstein,Joshua A. Weinstein,F. Ann Ran,F. Ann Ran,F. Ann Ran,Silvana Konermann,Silvana Konermann,Vineeta Agarwala,Vineeta Agarwala,Vineeta Agarwala,Yinqing Li,Yinqing Li,Eli J. Fine,Xuebing Wu,Ophir Shalem,Ophir Shalem,Thomas J. Cradick,Luciano A. Marraffini,Gang Bao,Feng Zhang,Feng Zhang +23 more
TL;DR: In this article, the Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to genomic loci by means of single-guide RNAs (sgRNAs) to enable genome editing.
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu,David A. Scott,David A. Scott,Joshua A. Weinstein,Joshua A. Weinstein,F. Ann Ran,F. Ann Ran,F. Ann Ran,Silvana Konermann,Silvana Konermann,Vineeta Agarwala,Vineeta Agarwala,Vineeta Agarwala,Yinqing Li,Yinqing Li,Eli J. Fine,Xuebing Wu,Ophir Shalem,Ophir Shalem,Thomas J. Cradick,Luciano A. Marraffini,Gang Bao,Feng Zhang,Feng Zhang +23 more
TL;DR: It is found that SpCas9 tolerates mismatches between guide RNA and target DNA at different positions in a sequence-dependent manner, sensitive to the number, position and distribution of mismatches.
Journal ArticleDOI
The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.
TL;DR: The effects of nanoparticle size on cellular interaction and in vivo pharmacokinetics, including cellular uptake, biodistribution and circulation half-life of nanoparticles are reviewed.
Journal ArticleDOI
Cell and molecular mechanics of biological materials
Gang Bao,Subra Suresh +1 more
TL;DR: The mechanical deformation of proteins and nucleic acids may provide key insights for understanding the changes in cellular structure, response and function under force, and offer new opportunities for the diagnosis and treatment of disease.
Journal ArticleDOI
Size-Dependent Endocytosis of Nanoparticles.
TL;DR: A thermodynamic model for receptor-mediated endocytosis of ligand-coated NPs is presented, and an optimal NP radius is identified at which the cellular uptake reaches a maximum of several thousand at physiologically relevant parameters, and it is shown that the cell uptake is regulated by membrane tension, and can be elaborately controlled by particle size.