Gang Ning

TL;DR: The iron dependence of ovarian cancer TICs renders them exquisitely sensitive in vivo to agents that induce iron-dependent cell death (ferroptosis) as well as iron chelators, and thus creates a metabolic vulnerability that can be exploited therapeutically.

TL;DR: The cloning and propagation of highly clonogenic, ‘ground state’ stem cells of the human intestine and colon are demonstrated and the stability of the epigenetic commitment programs of these stem cells, coupled with their unlimited replicative expansion and maintained clonogenicity, suggests certain advantages for their use in disease modelling and regenerative medicine.

TL;DR: This study reveals, for the first time, an entity (SCOUT) that is associated with serous cancer, expands the topography of altered PAX2 expression in the female genital tract mucosa and highlights another potential pathway disturbance involved in early serous carcinogenesis in the Fallopian tube.

TL;DR: This review addresses 4 categories of tubal epithelial change: metaplasias; nonmalignant atypias; potential precursors, including secretory cell outgrowths and p53 signatures; and tubal intraepithelial carcinomas.

TL;DR: Resolving this question will require accurately distinguishing progenitor from progeny tumour cells in HGSC and pinpointing where initial transformation and trans‐differentiation occur, whether in the tube or POSE, are critical to expectations from prophylactic salpingectomy and future approaches to pelvic serous cancer prevention.