G
Gang Wei
Researcher at Shanghai Jiao Tong University
Publications - 4
Citations - 45
Gang Wei is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: White adipose tissue & Adipose tissue. The author has an hindex of 2, co-authored 3 publications receiving 10 citations.
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Journal ArticleDOI
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
Gang Wei,Honglin Sun,Kai Dong,Libing Hu,Qi Wang,Qian Zhuang,Yan Zhu,Xianjing Zhang,Yaodi Shao,Huiru Tang,Zhenfei Li,Suzhen Chen,Junxi Lu,Yibing Wang,Xinxin Gan,Tao P. Zhong,Dingkun Gui,Xiaoyong Hu,Linhui Wang,Junli Liu +19 more
TL;DR: In this article, a bi-directional communication between ccRCC cells and perinephric adipose tissue (PAT) was described, and it was shown that if this cross-communication was short circuited by the pharmacological suppression of adipocyte browning via H89 or KT5720, the anti-tumor efficacy of the TKI, sunitinib, was enhanced.
Journal ArticleDOI
Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning
TL;DR: Results clearly show that as an effective BAT (as well as beige cells) activator, indirubin may have a protective effect on the prevention and treatment of obesity and its complications.
Journal ArticleDOI
Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis.
Honglin Sun,Gang Wei,He Liu,Danrui Xiao,Jianbo Huang,Junxi Lu,Ji Miao,Ji Miao,Junli Liu,Suzhen Chen +9 more
TL;DR: The results suggest that delaying the degradation of XBP1s by preventing ubiquitination might provide a strategic approach for reducing ER stress as an anti-diabetes therapy.
Journal ArticleDOI
Metabolic crosstalk between thermogenic adipocyte and cancer cell: Dysfunction and therapeutics.
TL;DR: The role of thermogenic adipose tissue in malignant cancer behavior has been largely overlooked as mentioned in this paper , however, emerging evidence suggests that beige/brown adipocytes play a key role in the development and progression of various cancers.