Journal ArticleDOI
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
Gang Wei,Honglin Sun,Kai Dong,Libing Hu,Qi Wang,Qian Zhuang,Yan Zhu,Xianjing Zhang,Yaodi Shao,Huiru Tang,Zhenfei Li,Suzhen Chen,Junxi Lu,Yibing Wang,Xinxin Gan,Tao P. Zhong,Dingkun Gui,Xiaoyong Hu,Linhui Wang,Junli Liu +19 more
TLDR
In this article, a bi-directional communication between ccRCC cells and perinephric adipose tissue (PAT) was described, and it was shown that if this cross-communication was short circuited by the pharmacological suppression of adipocyte browning via H89 or KT5720, the anti-tumor efficacy of the TKI, sunitinib, was enhanced.About:
This article is published in Cell Metabolism.The article was published on 2021-10-05. It has received 23 citations till now.read more
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Journal ArticleDOI
Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View
TL;DR: How the phenotypic and functional plasticity of macrophages allows their multifunctional response to the distinct microenvironments in developing atherosclerotic lesions and in developing malignant tumors is discussed.
Journal ArticleDOI
Adipose Tissue Remodeling in Pathophysiology.
TL;DR: This review elaborate on the distinct subtypes of adipocytes, their developmental origins and secretory roles, and the dynamic interplay at work within the tissue itself, as well as the relationship between adipose and disease states, including obesity, cachexia, and infectious diseases.
Journal ArticleDOI
Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 Alpha: A Double-Edged Sword in Prostate Cancer.
TL;DR: The procancer and anticancer effects of PGC-1 α in PCA are highlighted and a theoretical basis for targeting AMPK/PGC-1α to inhibit the development of PCA is provided.
Journal ArticleDOI
Restoring the epigenetically silenced lncRNA COL18A1-AS1 represses ccRCC progression by lipid browning via miR-1286/KLF12 axis
Yuenan (Linda) Liu,Jun Wang,Yi Shou,Wen-Juan Xu,Ziwei Huang,Jiaju Xu,Kailei Chen,Jingchong Liu,Di Liu,Huagen Liang,Hongmei Yang,Xiaoping Zhang +11 more
TL;DR: In this article , the authors found that COL18A1-AS1 was downregulated in clear cell renal cell carcinoma (ccRCC) and that higher expression indicated better prognosis.
Journal ArticleDOI
The function and mechanisms of action of circular RNAs in Urologic Cancer
Zi-hao Zhang,Yue Wang,Ya Zhang,Sheng-Feng Zheng,Tao Feng,Xi Tian,Mierxiati Abudurexiti,Zhen-da Wang,Wen-Kai Zhu,Jia-Qi Su,Hailiang Zhang,Guo Hai Shi,Ziliang Wang,Dalong Cao,Dingwei Ye +14 more
TL;DR: In this article , the authors summarized the properties of circRNAs and detail their function, focusing on the effects of circRNA on proliferation, metastasis, apoptosis, metabolism, and drug resistance in kidney, bladder, and prostate cancers.
References
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NIH Image to ImageJ: 25 years of image analysis
TL;DR: The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.
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Improved vectors and genome-wide libraries for CRISPR screening.
TL;DR: In this paper, Zhang et al. used a Genome-scale CRISPR Knock-Out (GeCKO) library to identify loss-of-function mutations in a melanoma model.
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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M Nieman,Hilary A. Kenny,Carla Penicka,Andras Ladanyi,Rebecca Buell-Gutbrod,Marion Zillhardt,Iris L. Romero,Mark S. Carey,Gordon B. Mills,Gökhan S. Hotamisligil,S. Diane Yamada,Marcus E. Peter,Katja Gwin,Ernst Lengyel +13 more
TL;DR: It is shown that primary human omental adipocytes promote homing, migration and invasion of ovarian cancer cells, and that adipokines including interleukin-8 (IL-8) mediate these activities, and adipocytes provide fatty acids for rapid tumor growth.
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Microenvironmental regulation of tumour angiogenesis
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