G
Gaofeng Fan
Researcher at ShanghaiTech University
Publications - 40
Citations - 1540
Gaofeng Fan is an academic researcher from ShanghaiTech University. The author has contributed to research in topics: Signal transduction & Medicine. The author has an hindex of 16, co-authored 31 publications receiving 1226 citations. Previous affiliations of Gaofeng Fan include Cold Spring Harbor Laboratory & Rutgers University.
Papers
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Journal ArticleDOI
Current insights into the regulation of programmed cell death by NF-kappaB.
TL;DR: There has been substantial progress in understanding NF-κB's mode of action in apoptosis and necrosis and the mechanisms that regulate its anti- vs proapoptotic activities, and recent developments shed new light on the role of NF-KappaB in many disease conditions including tumor development, tumor progression and anticancer treatment.
Journal ArticleDOI
Facile Creation of a Bionic Super‐Hydrophobic Block Copolymer Surface
Qiongdan Xie,Gaofeng Fan,Ning Zhao,Xiangdong Guo,Jie Xu,Jin-Yong Dong,Liaoyun Zhang,Yongjun Zhang +7 more
Book ChapterDOI
Regulation of Programmed Cell Death by NF-κB and its Role in Tumorigenesis and Therapy
TL;DR: The role of NF-kappaB in apoptotic and necrotic PCD, the mechanisms involved, and how its activity in the cell death response impacts cancer development, progression, and therapy are reviewed.
Journal ArticleDOI
Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification.
Yao Xiangping,Xuewen Cheng,Chong Wang,Miao Zhao,Xin-Xin Guo,Hui-Zhen Su,Lu-Lu Lai,Xiao-Huan Zou,Xue-Jiao Chen,Yu-Ying Zhao,En-Lin Dong,Ying-Qian Lu,Shuang Wu,Xiaojuan Li,Gaofeng Fan,Hongjie Yu,Jianfeng Xu,Ning Wang,Zhi-Qi Xiong,Wan-Jin Chen +19 more
TL;DR: These findings provide strong evidence that loss-of-function mutations of MYORG cause brain calcification in humans and mice.
Journal ArticleDOI
Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist.
Matthew J. Simmons,Gaofeng Fan,Gaofeng Fan,Wei-Xing Zong,Wei-Xing Zong,Wei-Xing Zong,Kurt Degenhardt,Eileen White,Eileen White,Céline Gélinas,Céline Gélinas +10 more
TL;DR: Bfl-1 associates with tBid to prevent activation of proapoptotic Bax and Bak, and it also interacts directly with Bak to antagonize Bak-mediated cell death, similar to Mcl-1, which is part of the protective function of NF-κB.