C
Céline Gélinas
Researcher at Center for Advanced Biotechnology and Medicine
Publications - 55
Citations - 11399
Céline Gélinas is an academic researcher from Center for Advanced Biotechnology and Medicine. The author has contributed to research in topics: REL & Transactivation. The author has an hindex of 32, co-authored 54 publications receiving 10788 citations. Previous affiliations of Céline Gélinas include University of Medicine and Dentistry of New Jersey & Rutgers University.
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Journal ArticleDOI
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Kurt Degenhardt,Robin Mathew,Robin Mathew,Brian Beaudoin,Brian Beaudoin,Kevin Bray,Diana Anderson,Guanghua Chen,Guanghua Chen,Guanghua Chen,Chandreyee Mukherjee,Chandreyee Mukherjee,Chandreyee Mukherjee,Yufang Shi,Céline Gélinas,Céline Gélinas,Yongjun Fan,Deirdre A. Nelson,Shengkan Jin,Eileen White +19 more
TL;DR: Limiting autophagy under conditions of nutrient limitation can restore cell death to apoptosis-refractory tumors, but this necrosis is associated with inflammation and accelerated tumor growth.
Journal ArticleDOI
Autophagy Suppresses Tumorigenesis through Elimination of p62
Robin Mathew,Cristina M. Karp,Brian Beaudoin,Brian Beaudoin,Nhan Vuong,Guanghua Chen,Hsin-Yi Chen,Kevin Bray,Anupama Reddy,Gyan Bhanot,Céline Gélinas,Céline Gélinas,Robert S. DiPaola,Vassiliki Karantza-Wadsworth,Eileen White +14 more
TL;DR: Defective autophagy is a mechanism for p62 upregulation commonly observed in human tumors that contributes directly to tumorigenesis likely by perturbing the signal transduction adaptor function of p62-controlling pathways critical for oncogenesis.
Journal ArticleDOI
Aberrant rel/nfkb genes and activity in human cancer.
Béatrice Rayet,Céline Gélinas +1 more
TL;DR: This review focuses on the status of the rel, nfkb and ikb genes and their activity in human tumors and their association with the onset or progression of malignancies.
Journal ArticleDOI
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Jessie Yanxiang Guo,Hsin-Yi Chen,Robin Mathew,Jing Fan,Anne M. Strohecker,Gizem Karsli-Uzunbas,Jurre J. Kamphorst,Guanghua Chen,Johanna M.S. Lemons,Vassiliki Karantza,Hilary A. Coller,Hilary A. Coller,Robert S. DiPaola,Céline Gélinas,Céline Gélinas,Joshua D. Rabinowitz,Eileen White +16 more
TL;DR: This "autophagy addiction" suggests that targeting autophagy and mitochondrial metabolism are valuable new approaches to treat these aggressive cancers.
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The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).
TL;DR: It is established that NF-κB directly regulates the expression of distinct prosurvival factors in the Bcl-2 family, such as B cl-xL and Bfl-1/A1, and the possibility that some of these factors may contribute to oncogenesis associated with aberrant Rel/NF-κBs activity.