G
Garrett Westmacott
Researcher at Public Health Agency of Canada
Publications - 48
Citations - 1698
Garrett Westmacott is an academic researcher from Public Health Agency of Canada. The author has contributed to research in topics: Immune system & Virus. The author has an hindex of 20, co-authored 46 publications receiving 1354 citations.
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Journal ArticleDOI
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
Nichole R. Klatt,Ryan Cheu,Kenzie Birse,Kenzie Birse,Alexander S. Zevin,Michelle Perner,Michelle Perner,Laura Noël-Romas,Laura Noël-Romas,Anna Christina. Grobler,Garrett Westmacott,Irene Y. Xie,Irene Y. Xie,Jennifer. Butler,Jennifer. Butler,Leila E. Mansoor,Lyle R. McKinnon,Lyle R. McKinnon,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Adam Burgener,Adam Burgener,Adam Burgener +26 more
TL;DR: Evidence is provided linking vaginal bacteria to microbicide efficacy through tenofovir depletion via bacterial metabolism through bacterial metabolism, which is linked to inconsistent results in women for HIV prevention.
Journal ArticleDOI
Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.
Kelly B. Arnold,Adam Burgener,Adam Burgener,Adam Burgener,Kenzie Birse,Kenzie Birse,Laura Romas,Laura Romas,Laura J. Dunphy,Kamnoosh Shahabi,Max Abou,Garrett Westmacott,Stuart McCorrister,Jessie Kwatampora,Billy Nyanga,Joshua Kimani,Joshua Kimani,Lindi Masson,Lindi Masson,Lenine J. P. Liebenberg,Salim S. Abdool Karim,Salim S. Abdool Karim,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Douglas A. Lauffenburger,Rupert Kaul,Rupert Kaul,Rupert Kaul,Lyle R. McKinnon,Lyle R. McKinnon,Lyle R. McKinnon +31 more
TL;DR: Data reveal strong linkages between mucosal cytokines, barrier function, proteases, and immune cell movement, and propose these as potential mechanisms that increase risk of HIV acquisition.
Journal ArticleDOI
Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract.
Alexander S. Zevin,Irene Y. Xie,Irene Y. Xie,Kenzie Birse,Kenzie Birse,Kelly B. Arnold,Laura Romas,Laura Romas,Garrett Westmacott,Richard M. Novak,Stuart McCorrister,Lyle R. McKinnon,Craig R. Cohen,Romel D. Mackelprang,Jairam R. Lingappa,Doug A. Lauffenburger,Nichole R. Klatt,Adam Burgener,Adam Burgener,Adam Burgener +19 more
TL;DR: It is finally demonstrated that soluble products derived from G. vaginalis inhibited wound healing, while those derived from L. iners did not, providing insight into functional mechanisms by which FGT bacterial communities affect epithelial barrier integrity.
Journal ArticleDOI
MicroRNA abundance is altered in synaptoneurosomes during prion disease
Amrit S. Boese,Reuben Saba,Kristyn Campbell,Anna Majer,Sarah J. Medina,Lynn Burton,Timothy F. Booth,Patrick Chong,Garrett Westmacott,Sucharita M. Dutta,Julian Saba,Stephanie A. Booth,Stephanie A. Booth +12 more
TL;DR: Changes in mature miRNA abundance within synaptoneurosomes isolated from prion-infected, as compared to mock- infected animals, are determined at asymptomatic and symptomatic stages of disease.
Journal ArticleDOI
Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers.
Adam Burgener,Julie Boutilier,Charles Wachihi,Joshua Kimani,Michael Carpenter,Garrett Westmacott,Keding Cheng,Terry B. Ball,Francis A. Plummer +8 more
TL;DR: The hypothesis is that innate immune factors in the genital tract may play a role in HIV-1 infection resistance, and this mechanism may help develop microbicides and/or vaccines against HIV- 1.