Gary A. Silverman

TL;DR: It is tentatively concluded that SCCA1 may play a cell-specific role in increasing cell number, a critical early step in microglial activation and brain inflammation, and differential display of genes in the microglia model system may help define patterns of expression associated with CNS disease, thereby identifying pathogenetic mechanisms and new therapeutic targets.

TL;DR: The data show that systemic T cell responsiveness is not eliminated by ingestion of soluble antigen, but rather is modulated in a manner previously detected in the humoral immune system.

TL;DR: The functional similarities between the intestinal cells of C. elegans and human hepatocytes are discussed and how a C. nematode model of α1-antitrypsin-deficiency can be used as a tool for identifying genetic modifiers and small molecule drugs is discussed.

TL;DR: The vulva of transgenic hermaphrodites is highly innervated by neuronal processes and by the VC4 and VC5 neurons that express GFP-tagged KCNL-2, which is proposed to function in the nervous system of C. elegans to regulate the rate of egg-laying.

TL;DR: Using combinatorial approaches of genetics and biochemistry in Caenorhabditis elegans, the true in vivo protease targets of the endogenous serpins can be elucidated.