G
Gary A. Silverman
Researcher at Washington University in St. Louis
Publications - 139
Citations - 13136
Gary A. Silverman is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Serpin & Gene. The author has an hindex of 41, co-authored 131 publications receiving 12186 citations. Previous affiliations of Gary A. Silverman include University of Pittsburgh & Washington & Jefferson College.
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Journal ArticleDOI
Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.
Cliff J. Luke,Charles Schick,Christopher Tsu,James C. Whisstock,James A. Irving,Dieter Brömme,Luiz Juliano,Guo-Ping Shi,Harold A. Chapman,Gary A. Silverman +9 more
TL;DR: Analysis of the mechanism of inhibition by SCCA1 revealed that the reactive site loop (RSL) is important for cysteine proteinase inhibition, and established the importance of a Pro residue in the P3' position for efficient inhibition of catS by both wild-type SccA1 and mutated S CCA2.
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A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency
Linda P. O’Reilly,Olivia S. Long,Murat Can Cobanoglu,Joshua A. Benson,Cliff J. Luke,Mark T. Miedel,Pamela Hale,David H. Perlmutter,Ivet Bahar,Gary A. Silverman,Stephen C. Pak +10 more
TL;DR: It is proposed that small animal models of genetic disorders combined with genome-wide RNAi screening and computational methods can be used to rapidly, economically and strategically prime the preclinical discovery pipeline for rare and neglected diseases with limited therapeutic options.
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Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells.
Torahiko Nakashima,Stephen C. Pak,Gary A. Silverman,Paul M. Spring,Mitchell J. Frederick,Gary L. Clayman +5 more
TL;DR: In this article, a panel of 18q21.3 YAC clones was used to map and cloned the headpin gene, which is composed of eight exons and seven introns.
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DNA accelerates the inhibition of human cathepsin V by serpins.
Poh Chee Ong,Sheena McGowan,Mary Catherine Pearce,James A. Irving,James A. Irving,Wan-Ting Kan,Sergei A. Grigoryev,Boris Turk,Gary A. Silverman,Klaudia Brix,Stephen P. Bottomley,James C. Whisstock,Robert N. Pike +12 more
TL;DR: This work presents the first example of modulation of serpin inhibition of cysteine proteases by a co-factor and reveals a mechanism for differential regulation of cathepsin proteolytic activity in a DNA-rich environment.
Journal ArticleDOI
Scca1 and scca2 are proteinase inhibitors that map to the serpin cluster at 18q21.3
Gary A. Silverman,Allison J. Bartuski,Sule Cataltepe,Eric R. Gornstein,Yoshiro Kamachi,Charles Schick,Yoshiki Uemura +6 more
TL;DR: Findings suggest that S CCA1 and SCCA2 are capable of regulating proteolytic events involved in both normal and pathologic processes, and high-molecular weight serine proteinase inhibitor (serpin) family.