G
Gary A. Silverman
Researcher at Washington University in St. Louis
Publications - 139
Citations - 13136
Gary A. Silverman is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Serpin & Gene. The author has an hindex of 41, co-authored 131 publications receiving 12186 citations. Previous affiliations of Gary A. Silverman include University of Pittsburgh & Washington & Jefferson College.
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Journal ArticleDOI
Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma.
Torahiko Nakashima,Ryuji Yasumatsu,Yuichiro Kuratomi,Muneyuki Masuda,Takashi Kuwano,Satoshi Toh,Toshiro Umezaki,Sule Cataltepe,Gary A. Silverman,Shizuo Komune +9 more
TL;DR: This study hypothesized that expression of SCCA1 is biologically disadvantageous to HNSCC cells and reported that this hypothesis was supported.
Journal ArticleDOI
An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z
Yan Wang,Murat Can Cobanoglu,Jie Li,Jie Li,Tunda Hidvegi,Tunda Hidvegi,Pamela Hale,Pamela Hale,Michael Ewing,Andrew S. Chu,Zhenwei Gong,Radhika Muzumdar,Stephen C. Pak,Stephen C. Pak,Gary A. Silverman,Gary A. Silverman,Ivet Bahar,David H. Perlmutter,David H. Perlmutter +18 more
TL;DR: It is shown that glibenclamide (GLB), a sulfonylurea drug that has been used broadly in clinical medicine as an oral hypoglycemic agent, promotes autophagic degradation of misfolded ATZ in mammalian cell line models of ATD.
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The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.
David J. Askew,Yuko S. Askew,Yukari Kato,Cliff J. Luke,Stephen C. Pak,Dieter Brömme,Gary A. Silverman +6 more
TL;DR: Mouse Serpinb3b extends the inhibitory repertoire of the mouse SCCA locus to include a second cross-class inhibitor with activity against both papain-like cysteine and trypsin-like serine proteinases, confirming that the genomic expansion of the clade B serpins in the mouse was associated with a functional diversification of inhibitory activity.
Journal ArticleDOI
Correlation of serpin–protease expression by comparative analysis of real-time PCR profiling data
Sunita Badola,Heidi Spurling,Keith E. Robison,Eric R. Fedyk,Gary A. Silverman,Jochen Strayle,Rosana Kapeller,Christopher Tsu +7 more
TL;DR: The most striking finding was the dramatic change observed in the regulation of expression between proteases and their cognate inhibitors in diseased tissues, suggesting the loss of regulated serpin-protease matched expression may underlie the imbalanced protease activity observed in pathological states.