G
Gary A. Silverman
Researcher at Washington University in St. Louis
Publications - 139
Citations - 13136
Gary A. Silverman is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Serpin & Gene. The author has an hindex of 41, co-authored 131 publications receiving 12186 citations. Previous affiliations of Gary A. Silverman include University of Pittsburgh & Washington & Jefferson College.
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BookDOI
Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity
Gary A. Silverman,David A. Lomas +1 more
TL;DR: Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition and are best known as critical regulators of both the thrombotic and fibrinolytic systems.
Journal ArticleDOI
Hepatic Fibrosis and Carcinogenesis in α1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders
TL;DR: In this paper, a 1-antitrypsin deficiency was found to reduce hepatic load of mutant AT and hepatic fibrosis in a mouse model by enhancing autophagic disposal of this mutant protein.
Journal ArticleDOI
A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma
Umasundari Sivaprasad,David J. Askew,Mark B. Ericksen,Aaron M. Gibson,Matthew T. Stier,Eric B. Brandt,Stacey A. Bass,Michael O. Daines,Jamila Chakir,Keith F. Stringer,Susan E. Wert,Jeffrey A. Whitsett,Timothy D. Le Cras,Marsha Wills-Karp,Gary A. Silverman,Gurjit K. Khurana Hershey +15 more
TL;DR: The data reveal a novel nonredundant role for Serpinb3a in mediating mucus production through regulation of SPDEF expression, which may be used to target mucus hypersecretion effectively.
Journal ArticleDOI
Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus
David J. Askew,Yuko S. Askew,Yukari Kato,Russell F. Turner,Ken Dewar,Jessica A. Lehoczky,Gary A. Silverman +6 more
TL;DR: It is found that the mouse clade B cluster at 1D showed nearly complete conservation of gene number, order, and orientation relative to those of 18q21, and the only exception was the squamous cell carcinoma antigen (SCCA) locus.
Journal ArticleDOI
A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover
Olivia S. Long,Joshua A. Benson,Joon Hyeok Kwak,Cliff J. Luke,Sager J. Gosai,Linda P. O’Reilly,Yan Wang,Jie Li,Anne C. Vetica,Mark T. Miedel,Donna B. Stolz,Simon C. Watkins,Stephan Züchner,David H. Perlmutter,Gary A. Silverman,Stephen C. Pak +15 more
TL;DR: Two studies allude to the existence of a novel proteostasis pathway that mechanistically links misfolded protein turnover to components of the systemic RNAi machinery.