G
Gary A. Wayman
Researcher at Washington State University
Publications - 67
Citations - 8267
Gary A. Wayman is an academic researcher from Washington State University. The author has contributed to research in topics: Dendritic spine & Ca2+/calmodulin-dependent protein kinase. The author has an hindex of 41, co-authored 66 publications receiving 7801 citations. Previous affiliations of Gary A. Wayman include Oregon Health & Science University & Vollum Institute.
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Journal ArticleDOI
Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation
Soren Impey,Karl Obrietan,Scott T. Wong,Steve Poser,Shigetoshi Yano,Gary A. Wayman,Jean-Christophe Deloulme,Guy C.-K. Chan,Daniel R. Storm +8 more
TL;DR: It is reported that extracellular signal-related protein kinase (ERK) signaling is obligatory for Ca2+-stimulated transcription in PC12 cells and hippocampal neurons and suggests that the activation of CREB by ERK plays a critical role in the formation of long lasting neuronal plasticity.
Journal ArticleDOI
Mechanism of calcium gating in small-conductance calcium-activated potassium channels
X. M. Xia,Bernd Fakler,Andre F. Rivard,Gary A. Wayman,Teresa L. Johnson-Pais,J. E. Keen,Takahiro M. Ishii,Birgit Hirschberg,Chris T. Bond,Svetlana Lutsenko,James Maylie,John P. Adelman +11 more
TL;DR: The mechanism of calcium gating is studied and it is found that small-conductance calcium-activated potassium channels are not gated by calcium binding directly to the channel α-subunits, instead, the functional SK channels are heteromeric complexes with calmodulin, which is constitutively associated with the α- subunits in a calcium-independent manner.
Journal ArticleDOI
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
Gary A. Wayman,Monika A. Davare,Hideaki Ando,Dale A. Fortin,Olga Varlamova,Hai-Ying M. Cheng,Daniel L. Marks,Karl Obrietan,Thomas R. Soderling,Richard H. Goodman,Soren Impey +10 more
TL;DR: It is shown that microRNA 132 (miR132) is an activity-dependent rapid response gene regulated by the cAMP response element-binding (CREB) protein pathway and proposed that the miR132–p250GAP pathway plays a key role in activity- dependent structural and functional plasticity.
Journal ArticleDOI
Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity
TL;DR: Key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior are summarized and the technical challenges of mapping cellular protein kinase signaling pathways are discussed.
Journal ArticleDOI
Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.
Gary A. Wayman,Soren Impey,Daniel L. Marks,Takeo Saneyoshi,Wilmon F. Grant,Victor A. Derkach,Thomas R. Soderling +6 more
TL;DR: An NMDA receptor-mediated, Ca2+-dependent signaling pathway that couples neuronal activity to dendritic arborization through enhanced Wnt synthesis and secretion is identified and contributes to dynamic remodeling of the dendrite architecture in response to neuronal activity during development.