G
Gary D. Ainge
Researcher at Industrial Research Limited
Publications - 19
Citations - 1604
Gary D. Ainge is an academic researcher from Industrial Research Limited. The author has contributed to research in topics: Phosphatidylinositol & Antigen. The author has an hindex of 16, co-authored 19 publications receiving 1527 citations. Previous affiliations of Gary D. Ainge include University of Otago & Callaghan Innovation.
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Journal ArticleDOI
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Yuki Kinjo,Emmanuel Tupin,Douglass Wu,Masakazu Fujio,Raquel Garcia-Navarro,Mohammed Rafii El Idrissi Benhnia,Mohammed Rafii El Idrissi Benhnia,Dirk M. Zajonc,Dirk M. Zajonc,Gil Ben-Menachem,Gary D. Ainge,Gavin F. Painter,Archana Khurana,Kasper Hoebe,Samuel M. Behar,Bruce Beutler,Ian A. Wilson,Moriya Tsuji,Timothy J. Sellati,Chi-Huey Wong,Mitchell Kronenberg +20 more
TL;DR: It is shown that mouse and human NKT cells also recognized glycolipids, specifically a diacylglycerol, from Borrelia burgdorferi, which causes Lyme disease, suggesting that NKT cell responses driven by T cell receptor–mediated glycolIPid recognition may provide protection against diverse pathogens.
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Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats
TL;DR: The results suggest that the nature of the sugar conjugate and the phenolic aglycon are both important determinants of anthocyanin absorption and excretion in rats and humans, and differences in bioavailability are due to variations in chemical structure.
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Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2
Maximiliano J. Jiménez-Dalmaroni,Nengming Xiao,Adam L. Corper,Petra Verdino,Gary D. Ainge,Gary D. Ainge,Dave S. Larsen,Gavin F. Painter,Pauline M. Rudd,Raymond A. Dwek,Kasper Hoebe,Bruce Beutler,Ian A. Wilson +12 more
TL;DR: Data indicate that the CD36 ectodomain is the only relevant domain for activation of TLR2 signaling pathway and that CD36 and CD14 have a non-redundant role for loading ligands ontoTLR2 in the plasma-membrane.
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Color in Fruit of the Genus Actinidia: Carotenoid and Chlorophyll Compositions
Tony K. McGhie,Gary D. Ainge +1 more
TL;DR: The carotenoid and chlorophyll contents in the fruit of four species ofactinidia were measured to determine the chemical basis of color in kiwifruit and related Actinidia species, suggesting that in fruit of A. deliciosa chloroplasts are not converted to chromoplasts as is typical for ripening fruit.
Journal ArticleDOI
Role of Phosphatidylinositol Mannosides in the Interaction between Mycobacteria and DC-SIGN
Nicole N. Driessen,Roy Ummels,J.J. Maaskant,Sudagar S. Gurcha,Gurdyal S. Besra,Gary D. Ainge,Gary D. Ainge,David S. Larsen,Gavin F. Painter,Christina M. J. E. Vandenbroucke-Grauls,Jeroen Geurtsen,Ben J. Appelmelk +11 more
TL;DR: It is concluded that, like ManLAM, PIM6 represents a bona fide DC-SIGN ligand but that other, as-yet-unknown, ligands dominate in the interaction between mycobacteria and DCs.