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Emmanuel Tupin
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 13
Citations - 1811
Emmanuel Tupin is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Natural killer T cell & Antigen. The author has an hindex of 11, co-authored 13 publications receiving 1727 citations. Previous affiliations of Emmanuel Tupin include French Institute of Health and Medical Research & Transgene SA.
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Journal ArticleDOI
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Yuki Kinjo,Emmanuel Tupin,Douglass Wu,Masakazu Fujio,Raquel Garcia-Navarro,Mohammed Rafii El Idrissi Benhnia,Mohammed Rafii El Idrissi Benhnia,Dirk M. Zajonc,Dirk M. Zajonc,Gil Ben-Menachem,Gary D. Ainge,Gavin F. Painter,Archana Khurana,Kasper Hoebe,Samuel M. Behar,Bruce Beutler,Ian A. Wilson,Moriya Tsuji,Timothy J. Sellati,Chi-Huey Wong,Mitchell Kronenberg +20 more
TL;DR: It is shown that mouse and human NKT cells also recognized glycolipids, specifically a diacylglycerol, from Borrelia burgdorferi, which causes Lyme disease, suggesting that NKT cell responses driven by T cell receptor–mediated glycolIPid recognition may provide protection against diverse pathogens.
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The unique role of natural killer T cells in the response to microorganisms
TL;DR: Natural killer T (NKT) cells combine features of the innate and adaptive immune systems and respond to innate cytokines produced by dendritic cells that have been activated by microbes.
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In Vivo Downregulation of T Helper Cell 1 Immune Responses Reduces Atherogenesis in Apolipoprotein E-Knockout Mice
E. Laurat,B. Poirier,Emmanuel Tupin,Giuseppina Caligiuri,Göran K. Hansson,Jean Bariety,Antonino Nicoletti +6 more
TL;DR: It is demonstrated that the Th1 immune response associated with atherosclerosis is deleterious and that a modulation of the Th 1 differentiation pathway may provide a new pharmacological tool to treat this disease.
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Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals.
Aaron J. Tyznik,Emmanuel Tupin,Niranjana A. Nagarajan,Min J. Her,Chris A. Benedict,Mitchell Kronenberg +5 more
TL;DR: iNKT cells have the ability to respond to a variety of microbes, including viruses, in an Ag-independent manner, suggesting they may play a broad role in antipathogen defenses despite their limited TCR repertoire.
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NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi
Emmanuel Tupin,Mohammed Rafii-El-Idrissi Benhnia,Yuki Kinjo,Rebeca L. Patsey,Christopher J. Lena,Matthew C. Haller,Melissa J. Caimano,Masakazu Imamura,Chi-Huey Wong,Shane Crotty,Justin D. Radolf,Timothy J. Sellati,Mitchell Kronenberg +12 more
TL;DR: The data are consistent with the hypothesis that the antigen-specific activation of Vα14i NKT cells is important for the prevention of persistent joint inflammation and spirochete clearance, and counter the long-standing notion that humoral rather than cellular immunity is sufficient to facilitate Lyme disease resolution.