Showing papers in "Kidney International in 1976"

TL;DR: New assay methods now have made it possible to begin to characterize osmoregulatory function in a more concrete and comprehensive way and also to use such information to analyze systematically certain clinical disorders of salt and water balance.

TL;DR: In incipient renal failure, indirect evidence of parathyroid hormone excess was found in the skeleton (empty osteoclastic lacunae, woven osteoid), and with the tetracycline double-labelling technique, a mineralization defect was demonstrable in many but not all patients.

TL;DR: The purpose of the present paper is to review the clinical, anatomical and biochemical changes in the central nervous system induced by hypo- and hypernatremic states, and to attempt to correlate these changes with the observedcentral nervous system disorders.

TL;DR: Observations suggest that this glomerulopathy is initiated by an unknown agent(s) which increased capillary permeability and progresses via thrombotic mechanisms which are prevented by heparin administration.

TL;DR: Using an ultrastructural immunoperoxidase technique, the distribution of endogenous albumin in the rat glomerulus was delineated under normal and abnormal hemodynamic conditions and it was found that glomerular barrier function depends upon the maintenance of normal blood flow conditions.

TL;DR: It is suggested that the fishes have already evolved the neural organization and other mechanisms necessary to induce intake of water in states of dehydration, and this complexity of behavior could account for the encephalization of drinking in the terrestrial animal.

TL;DR: The evidence for and against the proposed actions of prostaglandins in regulating blood pressure, renal blood flow and renal sodium and water excretion are surveyed.

TL;DR: It is formultated that the primary defect in this syndrome is related to hyperplasia of renomedullary interstitial cells and inappropriate release of renal prostaglandins giving rise to decreased sodium reabsorption, volume depletion and hypersecretion of renin and aldosterone.

TL;DR: The renal diluting segment (thick ascending limb of Henle's loop) reabsorbs sodium chloride in excess of water and is responsible for dilution of the urine as well as re absorption of a large fraction of the salt present in the glomerular ultrafiltrate.

TL;DR: The data indicate that a deficiency of 1,25 (OH)2D3 is at least partly responsible for the skeletal resistance to the calcemic action of PTH in uremia; Uremia, per se, may also contribute to this phenomenon.

TL;DR: The distal convoluted tubule can no longer be regarded as a single well-defined functional structure and is concluded that DCTl belongs to the functional segment mainly constituted by CCTl.

TL;DR: Evidence is provided that in patients with cirrhosis and ascites circulating AII is active in support of blood pressure, in direct suppression of renal renin release, and in stimulation of aldosterone release.

TL;DR: Whether the morphological results represent two distinct cell types or simply a variation in the structure of a single cell type must be considered in future structural-functional studies involving the ascending thick limb of Henle in the rat.

TL;DR: The results provide additional evidence for a close pathogenic relationship between IgA-associated glomerulonephritis and anaphylactoid purpura and immunofluorescence examination of skin biopsy specimens could prove of diagnostic value.

TL;DR: Why the nephrotoxicity of sisomicin or gentamicin involves chiefly the cortex, increases with the length of the treatment and can persist for several weeks after the last injection is explained.

TL;DR: The purpose of this review is to summarize some results obtained by the determination of enzymes of carbohydrate and energy metabolism in single portions of the rat nephron, and to discuss their possible relationships to renal transport processes.

TL;DR: It follows, therefore, that impairments in either maximal diluting or concentrating abilities will markedly decrease the range of water intake that the patient can tolerate.

TL;DR: The cellular actions of VP are divided into two major sequential biochemical events: the interaction of the hormone with its receptor and the effect of this reaction on cyclic AMP metabolism and the reactions by which cyclicAMP, in turn, may elicit changes in water permeability.

TL;DR: Semiquantitative analysis of the distribution of carbon particles within glomeruli revealed a predominately peripheral localization during early time periods, and increased relative concentration of particles within more central zones and in the lacis area at the vascular pole of the glomerulus at two to seven weeks, indicating that one of the mechanisms for clearance of materials from the mesangium was movement of particles in the direction of the Lacis area.

TL;DR: It is concluded that pharmacologic doses of 25-(OH)D3 are highly effective in healing bone lesions of children with terminal renal failure and such treatment requires strict clinical surveillance as 25-hydroxycholecalciferol intoxication may occur even in anephric patients.

TL;DR: Hypertension in endstage kidney disease is often associated with resetting of the body sodium/fluid=renin feedback mechanism, and it appears evident that additional mechanisms are also operative in maintaining end-stage renal hypertension.

TL;DR: In electron micrographs of proximal convoluted (PCT) and proximal straight tubules (PST), epithelial height was divided into five zones of equal thickness and circumferences of individual cells were estimated and quantitative three-dimensional cell models were constructed.

TL;DR: Results gained largely from double-perfused kidney tubules and from membrane vesicles are reported, the corresponding methods and their potency should be discussed.

TL;DR: Investigation of the magnocellular system of the hypothalamus suggests that vasopressin may play a role in the hypothalamic anterior pituitary adrenal axis and the cerebral spinal fluid pathway may be important in man if vasopression is found to have the memory consolidating effects which have been investigated in other animals.

TL;DR: This review has taken the opportunity to describe, and to speculate on, the probable site in the tubular cell of the defect in transcellular movement of the solute in a number of inborn errors of tubular transport.

TL;DR: The in vitro immune response of uremic and transplanted patients was studied by determining lymphocyte surface and functional markers and changes in surface or functional markers did not prove useful in predicting rejection episodes in transplants patients.

TL;DR: Hydstatic and oncotic water conductance of the rabbit proximal tubule changes with postnatal development and ultrastructural tracer studies suggest that the change in conductance is due to alteration of the paracellular pathway.