G
Gary LeRoy
Researcher at New York University
Publications - 60
Citations - 7475
Gary LeRoy is an academic researcher from New York University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 37, co-authored 58 publications receiving 6366 citations. Previous affiliations of Gary LeRoy include University of Pennsylvania & Rutgers University.
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The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
TL;DR: The finding that Mi2beta exists in a complex containing histone deacetylase and nucleosome remodeling activities suggests a role for chromatin reorganization in cancer metastasis.
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FACT, a Factor that Facilitates Transcript Elongation through Nucleosomes
TL;DR: The biochemical properties and polypeptide composition of FACT suggest that it is a novel protein factor that facilitates transcript elongation through nucleosome-induced block to productive transcription.
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Asymmetrically Modified Nucleosomes
Philipp Voigt,Gary LeRoy,William J. Drury,Barry M. Zee,Jinsook Son,David B. Beck,Nicolas L. Young,Benjamin A. Garcia,Danny Reinberg +8 more
TL;DR: It is demonstrated that nucleosomes in embryonic stem cells, fibroblasts, and cancer cells exist in both symmetrically and asymmetrically modified populations for histone H3 lysine 27 di/trimethylation (H3K27me2/3).
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The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription
TL;DR: It is reported that the double bromodomain proteins Brd2 and Brd3 associate preferentially in vivo with hyperacetylated chromatin along the entire lengths of transcribed genes.
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The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
Avnish Kapoor,Matthew S. Goldberg,Lara K. Cumberland,Kajan Ratnakumar,Miguel F. Segura,Patrick O. Emanuel,Silvia Menendez,Chiara Vardabasso,Gary LeRoy,Claudia I. Vidal,Claudia I. Vidal,David Polsky,Iman Osman,Benjamin A. Garcia,Eva Hernando,Emily Bernstein +15 more
TL;DR: It is demonstrated that mH2A is a critical component of chromatin that suppresses the development of malignant melanoma, a highly intractable cutaneous neoplasm.