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Nicolas L. Young
Researcher at Baylor College of Medicine
Publications - 64
Citations - 3810
Nicolas L. Young is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 24, co-authored 58 publications receiving 3189 citations. Previous affiliations of Nicolas L. Young include Florida State University & Purdue University.
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Journal ArticleDOI
How many human proteoforms are there
Ruedi Aebersold,Jeffrey N. Agar,I. Jonathan Amster,Mark S. Baker,Carolyn R. Bertozzi,Emily S. Boja,Catherine E. Costello,Benjamin F. Cravatt,Catherine Fenselau,Benjamin A. Garcia,Ying Ge,Jeremy Gunawardena,Ronald C. Hendrickson,Paul J. Hergenrother,Christian G. Huber,Alexander R. Ivanov,Ole N. Jensen,Michael C. Jewett,Neil L. Kelleher,Laura L. Kiessling,Nevan J. Krogan,Martin R. Larsen,Joseph A. Loo,Rachel R. Ogorzalek Loo,Emma Lundberg,Emma Lundberg,Michael J. MacCoss,Parag Mallick,Vamsi K. Mootha,Milan Mrksich,Tom W. Muir,Steven M. Patrie,James J. Pesavento,Sharon J. Pitteri,Henry Rodriguez,Alan Saghatelian,Wendy Sandoval,Hartmut Schlüter,Salvatore Sechi,Sarah A. Slavoff,Lloyd M. Smith,Michael Snyder,Paul M. Thomas,Mathias Uhlén,Jennifer E. Van Eyk,Marc Vidal,David R. Walt,Forest M. White,Evan R. Williams,Therese Wohlschlager,Vicki H. Wysocki,Nathan A. Yates,Nicolas L. Young,Bing Zhang +53 more
TL;DR: This work frames central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today, and uses this framework to assess existing data and ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?"
Journal ArticleDOI
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
Matthew F. Barber,Eriko Michishita-Kioi,Eriko Michishita-Kioi,Eriko Michishita-Kioi,Yuanxin Xi,Luisa Tasselli,Luisa Tasselli,Mitomu Kioi,Mitomu Kioi,Zarmik Moqtaderi,Ruth I. Tennen,Silvana Paredes,Silvana Paredes,Nicolas L. Young,Kaifu Chen,Kevin Struhl,Benjamin A. Garcia,Or Gozani,Wei Li,Katrin F. Chua,Katrin F. Chua +20 more
TL;DR: It is shown that SIRT7 is an NAD+-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells and demonstrates a pivotal role for Sirt7 in chromatin regulation, cellular transformation programs and tumour formation in vivo.
Journal ArticleDOI
Asymmetrically Modified Nucleosomes
Philipp Voigt,Gary LeRoy,William J. Drury,Barry M. Zee,Jinsook Son,David B. Beck,Nicolas L. Young,Benjamin A. Garcia,Danny Reinberg +8 more
TL;DR: It is demonstrated that nucleosomes in embryonic stem cells, fibroblasts, and cancer cells exist in both symmetrically and asymmetrically modified populations for histone H3 lysine 27 di/trimethylation (H3K27me2/3).
Journal ArticleDOI
High-throughput characterization of combinatorial histone codes
Nicolas L. Young,Peter A. DiMaggio,Mariana D. Plazas-Mayorca,Richard C. Baliban,Christodoulos A. Floudas,Benjamin A. Garcia +5 more
TL;DR: A novel method utilizing “saltless” pH gradient weak cation exchange-hydrophilic interaction liquid chromatography directly coupled to electron transfer dissociation (ETD) mass spectrometry for the automated on-line high throughput characterization of hypermodified combinatorial histone codes is presented.
Journal ArticleDOI
Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Wei Xie,Chunying Song,Nicolas L. Young,Adam S. Sperling,Feng Xu,Rupa Sridharan,Anne E. Conway,Benjamin A. Garcia,Kathrin Plath,Amander T. Clark,Michael Grunstein +10 more
TL;DR: The results suggest that K56Ac is involved in the human core transcriptional network of pluripotency, and more accurately reflects the epigenetic differences between hESCs and somatic cells than other active histone marks such as H3 K4 trimethylation and K9 acetylation.