D
David B. Beck
Researcher at National Institutes of Health
Publications - 65
Citations - 3391
David B. Beck is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 45 publications receiving 2137 citations. Previous affiliations of David B. Beck include Columbia University Medical Center & New York University.
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Journal ArticleDOI
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
David B. Beck,Marcela A. Ferrada,Keith A. Sikora,Amanda K. Ombrello,Jason C. Collins,Wuhong Pei,Nicholas Balanda,Daron L. Ross,Daniela Ospina Cardona,Zhijie Wu,Bhavisha A Patel,Kalpana Manthiram,Emma M. Groarke,Fernanda Gutierrez-Rodrigues,Patrycja Hoffmann,Sofia Rosenzweig,Shuichiro Nakabo,Laura W. Dillon,Christopher S. Hourigan,Wanxia L. Tsai,Sarthak Gupta,Carmelo Carmona-Rivera,Anthony J. Asmar,Lisha Xu,Hirotsugu Oda,Wendy Goodspeed,Karyl S. Barron,Michele Nehrebecky,Anne Jones,Ryan S. Laird,Natalie Deuitch,Dorota Rowczenio,Emily Rominger,Kristina V. Wells,Chyi-Chia Richard Lee,Weixin Wang,Megan Trick,James C. Mullikin,Gustaf Wigerblad,Stephen R. Brooks,Stefania Dell'Orso,Zuoming Deng,Jae Jin Chae,Alina Dulau-Florea,May Christine V. Malicdan,Danica Novacic,Robert A. Colbert,Mariana J. Kaplan,Massimo Gadina,Sinisa Savic,Helen J. Lachmann,Mones Abu-Asab,Benjamin D. Solomon,Kyle Retterer,William A. Gahl,Shawn M. Burgess,Ivona Aksentijevich,Neal S. Young,Katherine R. Calvo,Achim Werner,Daniel L. Kastner,Peter C. Grayson +61 more
TL;DR: Using a genotype-driven approach, this disorder is identified that connects seemingly unrelated adult-onset inflammatory syndromes and is named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
Journal ArticleDOI
Asymmetrically Modified Nucleosomes
Philipp Voigt,Gary LeRoy,William J. Drury,Barry M. Zee,Jinsook Son,David B. Beck,Nicolas L. Young,Benjamin A. Garcia,Danny Reinberg +8 more
TL;DR: It is demonstrated that nucleosomes in embryonic stem cells, fibroblasts, and cancer cells exist in both symmetrically and asymmetrically modified populations for histone H3 lysine 27 di/trimethylation (H3K27me2/3).
Journal ArticleDOI
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.
Jose M. Polo,Tania Dell’Oso,Stella M. Ranuncolo,Leandro Cerchietti,David B. Beck,Gustavo F. Da Silva,Gilbert G. Privé,Jonathan D. Licht,Ari Melnick +8 more
TL;DR: This work generated a peptide that specifically binds BCL6 and blocks corepressor recruitment in vivo and suggests that BTB domain peptide inhibitors may constitute a novel therapeutic agent for B-cell lymphomas.
Journal ArticleDOI
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription.
TL;DR: The mechanisms required for regulation of PR-Set7 and H4K20me1 levels are discussed and the many functions attributed to these proteins are attempted to unravel.
Journal ArticleDOI
Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage
Hisanobu Oda,Michael R. Hübner,David B. Beck,Michiel Vermeulen,Jerard Hurwitz,David L. Spector,Danny Reinberg +6 more
TL;DR: It is found that PR-Set7 is indeed undetectable during S phase and instead is detected during late G2, mitosis, and early G1, demonstrating a stringent spatiotemporal control of PR- set7 that is essential for preserving the genomic integrity of mammalian cells.