G
Gary LeRoy
Researcher at New York University
Publications - 60
Citations - 7475
Gary LeRoy is an academic researcher from New York University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 37, co-authored 58 publications receiving 6366 citations. Previous affiliations of Gary LeRoy include University of Pennsylvania & Rutgers University.
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Journal ArticleDOI
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Taro Hitosugi,Lu Zhou,Shannon Elf,Jun Fan,Hee-Bum Kang,Jae Ho Seo,Changliang Shan,Qing Dai,Liang Zhang,Jianxin Xie,Ting-Lei Gu,Peng Jin,Maša Alečković,Gary LeRoy,Yibin Kang,Jessica Sudderth,Ralph J. DeBerardinis,Chi Hao Luan,Georgia Z. Chen,Susan Muller,Dong M. Shin,Taofeek K. Owonikoko,Sagar Lonial,Martha Arellano,Hanna Jean Khoury,Fadlo R. Khuri,Benjamin H. Lee,Keqiang Ye,Titus J. Boggon,Sumin Kang,Chuan He,Jing Chen +31 more
TL;DR: Inhibition of PGAM1 by shRNA or a small molecule inhibitor PGMI-004A results in increased 3-PG and decreased 2-PG levels in cancer cells, leading to significantly decreased glycolysis, PPP flux and biosynthesis, as well as attenuated cell proliferation and tumor growth.
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Requirement of RSF and FACT for Transcription of Chromatin Templates in Vitro
TL;DR: In this article, a factor that facilitates activator-dependent transcription initiation on chromatin templates was purified, called remodeling and spacing factor (RSF), which has adenosine triphosphate-dependent nucleosome rearrangement and spacing activities.
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RNA-Mediated Feedback Control of Transcriptional Condensates.
Jonathan E. Henninger,Ozgur Oksuz,Krishna Shrinivas,Krishna Shrinivas,Ido Sagi,Gary LeRoy,Ming M. Zheng,J Owen Andrews,Alicia V. Zamudio,Charalampos Lazaris,Charalampos Lazaris,Nancy M. Hannett,Tong Ihn Lee,Phillip A. Sharp,Ibrahim I Cisse,Arup K. Chakraborty,Richard A. Young +16 more
TL;DR: Evidence from in-vitro and in vivo experiments support a model where RNAs produced during early steps in transcription initiation stimulate condensate formation, whereas the burst of RNAsproduced during elongation stimulate condensation.
Journal ArticleDOI
In Vivo Residue-specific Histone Methylation Dynamics
TL;DR: It is shown that quantitative proteomic approaches such as this can determine the dynamics of multiple methylated residues, an understudied portion of histone biology.
Journal ArticleDOI
BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones
Tomohiko Kanno,Yuka Kanno,Gary LeRoy,Eric I. Campos,Hong-Wei Sun,Stephen R. Brooks,Golnaz Vahedi,Tom D. Heightman,Benjamin A. Garcia,Danny Reinberg,Ulrich Siebenlist,John J. O'Shea,Keiko Ozato +12 more
TL;DR: It is shown that BRD4 occupies widespread genomic regions in mouse cells and directly stimulates elongation of both protein-coding transcripts and noncoding enhancer RNAs (eRNAs), in a manner dependent on bromodomain function.