G
Gary W. Conrad
Researcher at Kansas State University
Publications - 110
Citations - 4563
Gary W. Conrad is an academic researcher from Kansas State University. The author has contributed to research in topics: Keratan sulfate & Cornea. The author has an hindex of 37, co-authored 110 publications receiving 4336 citations. Previous affiliations of Gary W. Conrad include Centre national de la recherche scientifique & Mount Desert Island Biological Laboratory.
Papers
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Journal ArticleDOI
Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA).
A. Scott McCall,Stefan Kraft,Henry F. Edelhauser,George W. Kidder,Richard R. Lundquist,Helen E. Bradshaw,Zinaida Dedeic,Megan J. C. Dionne,Ethan M. Clement,Gary W. Conrad +9 more
TL;DR: Treatment of de-epithelialized human corneas with riboflavin + long-wavelength ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly and catalyzes cross-linking reactions that require production of singlet oxygen ((1)O(2)), whose half-life is extended by D(2)O.
Journal ArticleDOI
Molecular Cloning and Tissue Distribution of Keratocan BOVINE CORNEAL KERATAN SULFATE PROTEOGLYCAN 37A
Lolita M. Corpuz,James L. Funderburgh,Martha L. Funderburgh,George S. Bottomley,Sujatha Prakash,Gary W. Conrad +5 more
TL;DR: Funderburgh et al. as mentioned in this paper showed that the keratan sulfate-containing proteoglycans of bovine corneal stroma contain three unique core proteins designated 37A, 37B, and 25.
Journal ArticleDOI
Mimecan, the 25-kDa Corneal Keratan Sulfate Proteoglycan, Is a Product of the Gene Producing Osteoglycin
James L. Funderburgh,Lolita M. Corpuz,Mary R. Roth,Martha L. Funderburgh,Elena S. Tasheva,Gary W. Conrad +5 more
TL;DR: It is concluded that the full-length translation product of the gene producing osteoglycin is a corneal keratan sulfate proteoglycan, also present in many non-corneal tissues without keratan sulphate chains.
Journal ArticleDOI
Integrated genomic approaches implicate osteoglycin ( Ogn ) in the regulation of left ventricular mass
Enrico Petretto,Rizwan Sarwar,Ian C. Grieve,Han Lu,Mande K. Kumaran,Phillip J. Muckett,Jonathan Mangion,Blanche Schroen,Matthew A. Benson,Prakash P Punjabi,Sanjay K Prasad,Dudley J. Pennell,Chris Kiesewetter,Elena S. Tasheva,Lolita M. Corpuz,Megan D Webb,Gary W. Conrad,Theodore W. Kurtz,Vladimir Kren,Vladimir Kren,Judith Fischer,Norbert Hubner,Yigal M. Pinto,Michal Pravenec,Michal Pravenec,Timothy J. Aitman,Timothy J. Aitman,Stuart A. Cook,Stuart A. Cook +28 more
TL;DR: Osteoglycin (Ogn) is identified as a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM and a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice is confirmed.
Journal Article
Mimecan/osteoglycin-deficient mice have collagen fibril abnormalities.
Elena S. Tasheva,Anja Koester,Avelina Q. Paulsen,Alexander S. Garrett,Daniel L. Boyle,Harriet J. Davidson,Min Song,Niles Fox,Gary W. Conrad +8 more
TL;DR: It is demonstrated that mimecan, similar to other members of the SLRP gene family, has a role in regulating collagen fibrillogenesis in vivo and further studies, such as functional challenges, an evaluation of potential compensation by other proteins, and generation of double-knockouts will be necessary to fully uncover physiological functions of mime can in mice.