E
Enrico Petretto
Researcher at National University of Singapore
Publications - 174
Citations - 9547
Enrico Petretto is an academic researcher from National University of Singapore. The author has contributed to research in topics: Gene & Expression quantitative trait loci. The author has an hindex of 45, co-authored 154 publications receiving 7844 citations. Previous affiliations of Enrico Petretto include Imperial College London & Hammersmith Hospital.
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Journal ArticleDOI
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
Timothy J. Aitman,Rong Dong,Timothy J. Vyse,Penny J. Norsworthy,Michelle D. Johnson,Jennifer A. Smith,Jonathan Mangion,Cheri Roberton-Lowe,Amy J. Marshall,Enrico Petretto,Matthew D. Hodges,Gurjeet Bhangal,Sheetal Patel,Kelly Sheehan-Rooney,Mark A Duda,Paul R. Cook,David J. Evans,Jan Domin,Jonathan Flint,Joseph J. Boyle,Charles D. Pusey,H. Terence Cook +21 more
TL;DR: The finding that gene copy number polymorphism predisposes to immunologically mediated renal disease in two mammalian species provides direct evidence for the importance of genome plasticity in the evolution of genetically complex phenotypes, including susceptibility to common human disease.
Journal ArticleDOI
Repeatability of published microarray gene expression analyses.
John P. A. Ioannidis,David B. Allison,Catherine A. Ball,Issa Coulibaly,Xiangqin Cui,Aedín C. Culhane,Mario Falchi,Mario Falchi,Cesare Furlanello,Laurence Game,Giuseppe Jurman,Jon Mangion,Tapan Mehta,Michael Nitzberg,Grier P. Page,Grier P. Page,Enrico Petretto,Enrico Petretto,Vera van Noort +18 more
TL;DR: Evaluated the replication of data analyses in 18 articles on microarray-based gene expression profiling published in Nature Genetics in 2005–2006, finding that Repeatability of published microarray studies is apparently limited.
Journal ArticleDOI
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
Norbert Hubner,Caroline A. Wallace,Heike Zimdahl,Enrico Petretto,Herbert Schulz,Fiona Maciver,Michael Mueller,Oliver Hummel,Jan Monti,Vaclav Zidek,Alena Musilova,Vladimir Kren,Vladimir Kren,Helen C. Causton,Laurence Game,Gabriele Born,Sabine Schmidt,Anita Müller,Stuart A. Cook,Theodore W. Kurtz,John C. Whittaker,Michal Pravenec,Michal Pravenec,Timothy J. Aitman +23 more
TL;DR: This work mapped cis- and trans-regulatory control elements for expression of thousands of genes across the genome in the BXH/HXB panel of rat recombinant inbred strains and generated a data set of 73 candidate genes for hypertension that merit testing in human populations.
Journal ArticleDOI
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.
Alexandra Grubman,Alexandra Grubman,Alexandra Grubman,Gabriel Chew,John F. Ouyang,Guizhi Sun,Guizhi Sun,Guizhi Sun,Xin Yi Choo,Catriona McLean,Rebecca K. Simmons,Rebecca K. Simmons,Sam Buckberry,Sam Buckberry,Dulce B. Vargas-Landin,Dulce B. Vargas-Landin,Daniel Poppe,Daniel Poppe,Jahnvi Pflueger,Jahnvi Pflueger,Ryan Lister,Ryan Lister,Owen J. L. Rackham,Enrico Petretto,Jose M. Polo,Jose M. Polo,Jose M. Polo +26 more
TL;DR: In insights into the coordinated control of Alzheimer’s disease risk genes and their cell-type-specific contribution to disease susceptibility, single-nucleus RNA sequencing is applied to entorhinal cortex samples from control and Alzheimer's disease brains and identified transcription factor networks predicted to control disease progression in a cell-sub type-specific way.
Journal ArticleDOI
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Manuela Fanciulli,Penny J. Norsworthy,Enrico Petretto,Rong Dong,Lorraine Harper,Lavanya Kamesh,Joanne M. Heward,Stephen C. L. Gough,Adam J. de Smith,Alexandra I. F. Blakemore,Philippe Froguel,Philippe Froguel,Catherine J. Owen,Simon H. S. Pearce,Luis Augusto Teixeira,Loïc Guillevin,Deborah S. Cunninghame Graham,Charles D. Pusey,H. Terence Cook,Timothy J. Vyse,Timothy J. Aitman,Timothy J. Aitman +21 more
TL;DR: This work reports strong association between FCGR3B copy number and risk of systemic lupus erythematosus, microscopic polyangiitis and Wegener's granulomatosis in two independent cohorts from the UK and France.