S
Stuart A. Cook
Researcher at National University of Singapore
Publications - 329
Citations - 21412
Stuart A. Cook is an academic researcher from National University of Singapore. The author has contributed to research in topics: Dilated cardiomyopathy & Fibrosis. The author has an hindex of 65, co-authored 300 publications receiving 16163 citations. Previous affiliations of Stuart A. Cook include University of Southern California & Medical Research Council.
Papers
More filters
Journal ArticleDOI
Truncations of Titin Causing Dilated Cardiomyopathy
Daniel S. Herman,Lien Lam,Matthew R.G. Taylor,Libin Wang,Polakit Teekakirikul,Danos C. Christodoulou,Lauren Conner,Steven R. DePalma,Barbara McDonough,Elizabeth Sparks,Debbie Lin Teodorescu,Allison L. Cirino,Nicholas R. Banner,Dudley J. Pennell,Sharon L. Graw,Marco Merlo,Andrea Di Lenarda,Gianfranco Sinagra,J. Martijn Bos,Michael J. Ackerman,Richard N. Mitchell,Charles E. Murry,Neal K. Lakdawala,Carolyn Y. Ho,Paul J.R. Barton,Stuart A. Cook,Luisa Mestroni,Jonathan G. Seidman,Christine E. Seidman +28 more
TL;DR: Incorporation of sequencing approaches that detect TTN truncations into genetic testing for dilated cardiomyopathy should substantially increase test sensitivity, thereby allowing earlier diagnosis and therapeutic intervention for many patients with dilated heart disease.
Journal ArticleDOI
Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy.
Ankur Gulati,Andrew Jabbour,Tevfik F Ismail,Kaushik Guha,Jahanzaib Khwaja,Sadaf Raza,Kishen Morarji,Tristan D.H. Brown,Nizar Ismail,Marc R. Dweck,Elisa Di Pietro,Michael Roughton,Ricardo Wage,Yousef Daryani,Rory O'Hanlon,Mary N. Sheppard,Francisco Alpendurada,Alexander R. Lyon,Stuart A. Cook,Martin R. Cowie,Ravi Assomull,Dudley J. Pennell,Sanjay K Prasad +22 more
TL;DR: Risk stratification of patients with nonischemic dilated cardiomyopathy is primarily based on left ventricular ejection fraction (LVEF), and superior prognostic factors may improve patient selection for implantable cardioverter-defibrillators (ICDs) and other management decisions.
Journal ArticleDOI
Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples
Roddy Walsh,K Thomson,James S. Ware,James S. Ware,Birgit Funke,Jessica Woodley,Karen McGuire,Francesco Mazzarotto,Francesco Mazzarotto,Edward Blair,Anneke Seller,Jenny C. Taylor,Eric Vallabh Minikel,Daniel G. MacArthur,Martin Farrall,Stuart A. Cook,Hugh Watkins,Hugh Watkins +17 more
TL;DR: Improved analytical approaches that evaluate which genes and variant classes are interpretable are outlined and it is proposed that these will increase the clinical utility of testing across a range of Mendelian diseases.
Journal ArticleDOI
Anatomically Constrained Neural Networks (ACNNs): Application to Cardiac Image Enhancement and Segmentation
Ozan Oktay,Enzo Ferrante,Konstantinos Kamnitsas,Mattias P. Heinrich,Wenjia Bai,Jose Caballero,Stuart A. Cook,Antonio de Marvao,Timothy J W Dawes,Declan P. O'Regan,Bernhard Kainz,Ben Glocker,Daniel Rueckert +12 more
TL;DR: In this article, a generic training strategy that incorporates anatomical prior knowledge into CNNs through a new regularization model, which is trained end-to-end, encourages models to follow the global anatomical properties of the underlying anatomy via learnt non-linear representations of the shape.
Journal ArticleDOI
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
Norbert Hubner,Caroline A. Wallace,Heike Zimdahl,Enrico Petretto,Herbert Schulz,Fiona Maciver,Michael Mueller,Oliver Hummel,Jan Monti,Vaclav Zidek,Alena Musilova,Vladimir Kren,Vladimir Kren,Helen C. Causton,Laurence Game,Gabriele Born,Sabine Schmidt,Anita Müller,Stuart A. Cook,Theodore W. Kurtz,John C. Whittaker,Michal Pravenec,Michal Pravenec,Timothy J. Aitman +23 more
TL;DR: This work mapped cis- and trans-regulatory control elements for expression of thousands of genes across the genome in the BXH/HXB panel of rat recombinant inbred strains and generated a data set of 73 candidate genes for hypertension that merit testing in human populations.