G
Gautam Chaudhuri
Researcher at University of California, Los Angeles
Publications - 153
Citations - 13514
Gautam Chaudhuri is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Gene expression & Apoptosis. The author has an hindex of 48, co-authored 153 publications receiving 12897 citations. Previous affiliations of Gautam Chaudhuri include Naval Medical Center San Diego & Meharry Medical College.
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Journal ArticleDOI
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
TL;DR: The vascular effects of EDRF released from perfused bovine intrapulmonary artery and vein were compared with the effects of NO delivered by superfusion over endothelium-denuded arterial and venous strips arranged in a cascade to determine whether nitric oxide (NO) is responsible for the vascular smooth muscle relaxation elicited by endothelia-derived relaxing factor (EDRF).
Journal ArticleDOI
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Hiroki Kaneko,Sami Dridi,Valeria Tarallo,Bradley D. Gelfand,Benjamin J. Fowler,Won Gil Cho,Won Gil Cho,Mark E. Kleinman,Steven L. Ponicsan,William W. Hauswirth,Vince A. Chiodo,Katalin Karikó,Jae-Wook Yoo,Dong Ki Lee,Majda Hadziahmetovic,Ying Qing Song,Smita Misra,Gautam Chaudhuri,Frank W. Buaas,Robert E. Braun,David R. Hinton,Qing-qing Zhang,Hans E. Grossniklaus,Jan Provis,Michele C. Madigan,Ann H. Milam,Nikki L. Justice,Romulo Albuquerque,Alexander D Blandford,Sasha Bogdanovich,Yoshio Hirano,Jassir Witta,Elaine Fuchs,Dan R. Littman,Balamurali K. Ambati,Balamurali K. Ambati,Charles M. Rudin,Mark M.W. Chong,Patrick Provost,Jennifer F. Kugel,James A. Goodrich,Joshua L. Dunaief,Judit Z. Baffi,Jayakrishna Ambati +43 more
TL;DR: Findings reveal a miRNA-independent cell survival function for DICER1 involving retrotransposon transcript degradation, show that Alu RNA can directly cause human pathology, and identify new targets for a major cause of blindness.
Journal ArticleDOI
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
Valeria Tarallo,Yoshio Hirano,Bradley D. Gelfand,Sami Dridi,Nagaraj Kerur,Younghee Kim,Won Gil Cho,Won Gil Cho,Hiroki Kaneko,Benjamin J. Fowler,Sasha Bogdanovich,Romulo Albuquerque,William W. Hauswirth,Vince A. Chiodo,Jennifer F. Kugel,James A. Goodrich,Steven L. Ponicsan,Gautam Chaudhuri,Michael P. Murphy,Joshua L. Dunaief,Balamurali K. Ambati,Balamurali K. Ambati,Yuichiro Ogura,Jae Wook Yoo,Dong Ki Lee,Patrick Provost,David R. Hinton,Gabriel Núñez,Judit Z. Baffi,Mark E. Kleinman,Jayakrishna Ambati +30 more
TL;DR: It is shown that DICER1 deficit or Alu RNA exposure activates the NLRP3 inflammasome and triggers TLR-independent MyD88 signaling via IL18 in the RPE and reveals a function of the inflammaome outside the immune system and an immunomodulatory action of mobile elements.
Journal ArticleDOI
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis
TL;DR: It is established that basal NO release from endothelium-intact aortic rings depends on circulating estradiol concentration and offers an explanation for the protective effect of estradio against the development of atherosclerosis.
Journal Article
Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation.
TL;DR: Both pyrogallol and oxyhemoglobin enhanced arterial contractile responsiveness to phenylephrine in an endothelium-dependent manner, whereas indomethacin was without effect.