J
Jon M. Fukuto
Researcher at Sonoma State University
Publications - 172
Citations - 17037
Jon M. Fukuto is an academic researcher from Sonoma State University. The author has contributed to research in topics: Nitroxyl & Nitric oxide. The author has an hindex of 69, co-authored 166 publications receiving 15632 citations. Previous affiliations of Jon M. Fukuto include Oklahoma State University Center for Health Sciences & University of California, Los Angeles.
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Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle
TL;DR: It is reported here that electrical field stimulation of isolated strips of rabbit corpus cavernosum promotes the endogenous formation and release of nitric oxide, nitrite, and cyclic GMP, and indicates that penile erection may be mediated by NO generated in response to nonadrenergic-noncholinergic neurotransmission.
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Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.
TL;DR: It is reported here that the primary decomposition product of NO in aerobic aqueous solution is NO2- and that further oxidation to NO3- requires the presence of additional oxidizing species such as oxyhemoproteins.
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Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.
Tomoaki Ida,Tomohiro Sawa,Hideshi Ihara,Yukihiro Tsuchiya,Yasuo Watanabe,Yoshito Kumagai,Makoto Suematsu,Hozumi Motohashi,Shigemoto Fujii,Tetsuro Matsunaga,Masayuki Yamamoto,Katsuhiko Ono,Nelmi O. Devarie-Baez,Ming Xian,Jon M. Fukuto,Takaaki Akaike +15 more
TL;DR: It is proposed that reactive Cys persulfides and S-polythiolation have critical regulatory functions in redox cell signaling and H2S may act primarily as a marker for the biologically active of persulfide species.
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Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers.
TL;DR: This review focuses on the chemistry of the reversible oxidation of thiolates in proteins, with a particular emphasis on the critical thiolate found in protein tyrosine phosphatases as an example.
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Shear stress-induced release of nitric oxide from endothelial cells grown on beads.
TL;DR: Observations indicate that fluid shear stress causes the generation of EDRF with properties of nitric oxide from aortic endothelial cells and that the bioassay system described may be useful for studying the mechanism of mechanochemical coupling that leads to Nitric oxide generation.