V
Valeria Tarallo
Researcher at University of Kentucky
Publications - 42
Citations - 2564
Valeria Tarallo is an academic researcher from University of Kentucky. The author has contributed to research in topics: Angiogenesis & RNA. The author has an hindex of 20, co-authored 42 publications receiving 2227 citations. Previous affiliations of Valeria Tarallo include National Research Council.
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Journal ArticleDOI
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Hiroki Kaneko,Sami Dridi,Valeria Tarallo,Bradley D. Gelfand,Benjamin J. Fowler,Won Gil Cho,Won Gil Cho,Mark E. Kleinman,Steven L. Ponicsan,William W. Hauswirth,Vince A. Chiodo,Katalin Karikó,Jae-Wook Yoo,Dong Ki Lee,Majda Hadziahmetovic,Ying Qing Song,Smita Misra,Gautam Chaudhuri,Frank W. Buaas,Robert E. Braun,David R. Hinton,Qing-qing Zhang,Hans E. Grossniklaus,Jan Provis,Michele C. Madigan,Ann H. Milam,Nikki L. Justice,Romulo Albuquerque,Alexander D Blandford,Sasha Bogdanovich,Yoshio Hirano,Jassir Witta,Elaine Fuchs,Dan R. Littman,Balamurali K. Ambati,Balamurali K. Ambati,Charles M. Rudin,Mark M.W. Chong,Patrick Provost,Jennifer F. Kugel,James A. Goodrich,Joshua L. Dunaief,Judit Z. Baffi,Jayakrishna Ambati +43 more
TL;DR: Findings reveal a miRNA-independent cell survival function for DICER1 involving retrotransposon transcript degradation, show that Alu RNA can directly cause human pathology, and identify new targets for a major cause of blindness.
Journal ArticleDOI
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
Valeria Tarallo,Yoshio Hirano,Bradley D. Gelfand,Sami Dridi,Nagaraj Kerur,Younghee Kim,Won Gil Cho,Won Gil Cho,Hiroki Kaneko,Benjamin J. Fowler,Sasha Bogdanovich,Romulo Albuquerque,William W. Hauswirth,Vince A. Chiodo,Jennifer F. Kugel,James A. Goodrich,Steven L. Ponicsan,Gautam Chaudhuri,Michael P. Murphy,Joshua L. Dunaief,Balamurali K. Ambati,Balamurali K. Ambati,Yuichiro Ogura,Jae Wook Yoo,Dong Ki Lee,Patrick Provost,David R. Hinton,Gabriel Núñez,Judit Z. Baffi,Mark E. Kleinman,Jayakrishna Ambati +30 more
TL;DR: It is shown that DICER1 deficit or Alu RNA exposure activates the NLRP3 inflammasome and triggers TLR-independent MyD88 signaling via IL18 in the RPE and reveals a function of the inflammaome outside the immune system and an immunomodulatory action of mobile elements.
Journal ArticleDOI
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
Benjamin J. Fowler,Bradley D. Gelfand,Younghee Kim,Nagaraj Kerur,Valeria Tarallo,Yoshio Hirano,Shoba Amarnath,Daniel H. Fowler,Marta Radwan,Mark T. Young,Keir Pittman,Paul Kubes,Hitesh K. Agarwal,Keykavous Parang,David R. Hinton,Ana Bastos-Carvalho,Shengjian Li,Tetsuhiro Yasuma,Takeshi Mizutani,Reo Yasuma,Charles B. Wright,Jayakrishna Ambati +21 more
TL;DR: NRTIs improved outcomes in several NLRP3 inflammasome-dependent mouse models of inflammation, including age-related macular degeneration and graft-versus-host disease, and suggest that NRTIs are ripe for drug repurposing in P2X7-driven diseases.
Journal ArticleDOI
Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.
Roberto Bianco,Roberta De Rosa,Vincenzo Damiano,Gennaro Daniele,Teresa Gelardi,Sonia Garofalo,Valeria Tarallo,Sandro De Falco,Davide Melisi,Roberto Benelli,Adriana Albini,Anderson J. Ryan,Fortunato Ciardiello,Giampaolo Tortora +13 more
TL;DR: This study shows that VEGFR-1 contributes to anti-EGFR drug resistance in different human cancer cells, and vandetanib inhibits VEGfr-1 activation, cell proliferation, and migration, suggesting its potential utility in patients resistant to EGFR inhibitors.
Journal ArticleDOI
Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth
Won Gil Cho,Romulo Albuquerque,Mark E. Kleinman,Valeria Tarallo,Adelaide Greco,Miho Nozaki,Martha G. Green,Judit Z. Baffi,Balamurali K. Ambati,Massimo De Falco,Jonathan Steven Alexander,Arturo Brunetti,Sandro De Falco,Jayakrishna Ambati +13 more
TL;DR: These findings introduce TLR3 activation as a method of jointly suppressing blood and lymphatic neovascularization and simultaneously raise new concerns about the undesirable effects of siRNAs on both circulatory systems.