Geltrude Mingrone

TL;DR: Restoration of the first-phase insulin secretion and normalization of insulin sensitivity in type 2 diabetic subjects after malabsorptive bariatric surgery seem to be related to the reduction of the effect of some intestinal factor(s) resulting from intestinal bypass.

TL;DR: Surgery is more effective than medical treatment in achieving diabetes remission and tighter glycemic control, and shorter diabetes duration, lower fasting glycemia before surgery, and GD versus GO procedures independently predict higher rates of remission, whereas baseline HbA1c and waist circumference predict improved gly glucose control.

TL;DR: Experts from the Diabetes Surgery Summit consensus conference series provide guidance for the management of patients while surgery is delayed and for postoperative surveillance and offer a strategy to prioritise bariatric and metabolic surgery candidates on the basis of the diseases that are most likely to be ameliorated postoperatively.

TL;DR: In obese subjects with hyperinsulinemia and high levels of free fatty acids, insulin hepatic clearance is impaired, while theglomerular filtration rate, renal plasma flow and albumin excretion are increased, suggesting a state of renal vasodilatation leading to an abnormally transmitted arterial pressure to the glomerular capillaries through a dilated afferent arteriole.

TL;DR: In obese diabetic patients lipid malabsorption induced by BPD causes a definite enhancement of insulin sensitivity and glucose tolerance before the surgery has major effects on body weight, suggesting that lowered plasma lipids, rather than weight loss, are the cause of the reversibility of insulin resistance.