G
Genaro Hernandez
Researcher at San Diego State University
Publications - 18
Citations - 1251
Genaro Hernandez is an academic researcher from San Diego State University. The author has contributed to research in topics: Mitophagy & Autophagy. The author has an hindex of 11, co-authored 16 publications receiving 1022 citations. Previous affiliations of Genaro Hernandez include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
Chengqun Huang,Allen M. Andres,Eric P. Ratliff,Genaro Hernandez,Pamela Lee,Roberta A. Gottlieb +5 more
TL;DR: It is found that depletion of p62 attenuated mitophagy and exacerbated cell death in HL-1 cardiomyocytes subjected to sI results reveal for the first time the crucial role of Parkin andMitophagy in cardioprotection.
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FGF21 Regulates Sweet and Alcohol Preference
Saswata Talukdar,Bryn M. Owen,Parkyong Song,Genaro Hernandez,Yuan Zhang,Yingjiang Zhou,William T. Scott,Bhavna S. Paratala,Tod Turner,Andrew H. Smith,Barbara Bernardo,Christian P. Müller,Christian P. Müller,Hao Tang,David J. Mangelsdorf,Bryan Goodwin,Steven A. Kliewer +16 more
TL;DR: It is shown that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys, raising the possibility that F GF21 administration could affect nutrient preference and other reward behaviors in humans.
Journal ArticleDOI
Mitophagy is required for acute cardioprotection by simvastatin.
Allen M. Andres,Genaro Hernandez,Pamela Lee,Chengqun Huang,Eric P. Ratliff,Jon Sin,Christine A Thornton,Marichris V. Damasco,Roberta A. Gottlieb +8 more
TL;DR: It is shown that autophagy and mitophagy are required for preconditioning in statin-mediated cardioprotection and the effects are mediated through inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.
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MitoTimer: A novel tool for monitoring mitochondrial turnover
Genaro Hernandez,Christine A Thornton,Aleksandr Stotland,Diana Lui,Jon Sin,Jennifer Ramil,Najib Magee,Allen M. Andres,Giovanni Quarato,Raquel S. Carreira,M. Richard Sayen,Roland Wolkowicz,Roberta A. Gottlieb +12 more
TL;DR: In this article, the authors used a tetracycline-inducible promoter construct to regulate the expression of fluorescent Timer, a fluorescent reporter for mitochondrial dynamics, which can reveal new insights into mitochondrial dynamics within cells.
Journal ArticleDOI
New flexible synthesis of pyrazoles with different, functionalized substituents at C3 and C5.
Douglas B. Grotjahn,Sang Van,David Combs,Daniel A. Lev,Christian Schneider,Marc C. Rideout,Christoph Meyer,Genaro Hernandez,Lupe Mejorado +8 more
TL;DR: The significance of the ligands made here is that by placing a ligating side chain on a ring carbon (C3), rather than on a rings nitrogen, the ring nitrogen not bound to the metal and its attached proton will be available for hydrogen bonding, depending on the steric environment created by R at C5.