G
Gencheng Han
Publications - Â 4
Citations - Â 664
Gencheng Han is an academic researcher. The author has contributed to research in topics: BALB/c & Vaccine efficacy. The author has an hindex of 2, co-authored 4 publications receiving 402 citations.
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Journal ArticleDOI
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy.
Hongjing Gu,Qi Chen,Guan Yang,Lei He,Hang Fan,Yong Qiang Deng,Yanxiao Wang,Yue Teng,Zhongpeng Zhao,Yujun Cui,Li Yuchang,Xiaofeng Li,Jiangfan Li,Na Na Zhang,Xiaolan Yang,Shaolong Chen,Yan Guo,Guangyu Zhao,Xiliang Wang,De Yan Luo,Hui Wang,Xiao Yang,Yan Li,Gencheng Han,Yuxian He,Xiaojun Zhou,Shusheng Geng,Xiaoli Sheng,Shibo Jiang,Shihui Sun,Cheng-Feng Qin,Yusen Zhou +31 more
TL;DR: A mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia is developed, and a panel of adaptive mutations potentially associated with the increased virulence are revealed.
Posted ContentDOI
Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy
Hongjing Gu,Qi Chen,Guan Yang,Lei He,Hang Fan,Yong-Qiang Deng,Yanxiao Wang,Yue Teng,Zhongpeng Zhao,Yujun Cui,Yuchang Li,Xiaofeng Li,Jiangfan Li,Na-Na Zhang,Xiaolan Yang,Shaolong Chen,Guangyu Zhao,Xiliang Wang,Deyan Luo,Hui Wang,Xiao Yang,Yan Li,Gencheng Han,Yuxian He,Xiaojun Zhou,Shusheng Geng,Xiaoli Sheng,Bojiang Shi,Shihui Sun,Cheng-Feng Qin,Zhou Yusen +30 more
TL;DR: It is found that mouse-adapted SARS-CoV-2 at passage 6 (MACSp6) efficiently infected both aged and young wild-type BALB/c mice, resulting in moderate pneumonia as well as inflammatory responses.
Posted ContentDOI
Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice
Yansong Sun,Gencheng Han,Wenjin Wei,Zhongyu Hu,Shihui Sun,Lei He,Zhongpeng Zhao,Hongjing Gu,Tiecheng Wang,Xiaolan Yang,Shaolong Chen,Yong-Qiang Deng,Jiangfan Li,Jian Zhao,Liang Li,Xinwang Li,Peng He,Ge Li,Hao Li,Chunrui Gao,Lang Xiaoling,Shusheng Geng,Xin Wang,Guoqiang Fei,Yan Li,Yuwei Gao,Xin Fang,Yuee Zhao +27 more
TL;DR: Protective efficacy of a SARS-CoV-2 RBD-Fc subunit vaccine with Receptor binding domain fused with the Fc domain of human IgG1 is confirmed.
Patent
COVID-19 vaccine, preparation methods and applications
Zhou Yusen,Guangyu Zhao,Hongjing Gu,Shihui Sun,He Lei,Li Yan,Gencheng Han,Lang Xiaoling,Liu Jie,Shusheng Geng,Xiaoli Sheng +10 more
TL;DR: In this paper, a dominant antigen (RBD) epitope of the COVID-19 vaccine is obtained by screening, and in order to improve the immunogenicity of the antigen, the antigen is connected to immunoglobulin to prepare an RBD-Fc fusion protein.