H
Hongjing Gu
Researcher at Academy of Military Medical Sciences
Publications - 37
Citations - 2272
Hongjing Gu is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 15, co-authored 32 publications receiving 1297 citations.
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Journal ArticleDOI
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.
Ke Wang,Wei Chen,Zheng Zhang,Yong-Qiang Deng,Jian-Qi Lian,Peng Du,Ding Wei,Yang Zhang,Xiu-Xuan Sun,Li Gong,Xu Yang,Lei He,Lei Zhang,Zhiwei Yang,Jie-Jie Geng,Ruo Chen,Zhang Hai,Bin Wang,Yu-Meng Zhu,Gang Nan,Jian-Li Jiang,Ling Li,Jiao Wu,Peng Lin,Wan Huang,Liangzhi Xie,Zhaohui Zheng,Kui Zhang,Jinlin Miao,Hong-Yong Cui,Min Huang,Jun Zhang,Ling Fu,Xiang-Min Yang,Zhongpeng Zhao,Shihui Sun,Hongjing Gu,Zhe Wang,Chun-Fu Wang,Yacheng Lu,Liu Yingying,Qing-Yi Wang,Huijie Bian,Ping Zhu,Zhi-Nan Chen +44 more
TL;DR: A novel virus entry route, CD147-spike protein, is revealed, which provides an important target for developing specific and effective drug against COVID-19.
Journal ArticleDOI
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy.
Hongjing Gu,Qi Chen,Guan Yang,Lei He,Hang Fan,Yong Qiang Deng,Yanxiao Wang,Yue Teng,Zhongpeng Zhao,Yujun Cui,Li Yuchang,Xiaofeng Li,Jiangfan Li,Na Na Zhang,Xiaolan Yang,Shaolong Chen,Yan Guo,Guangyu Zhao,Xiliang Wang,De Yan Luo,Hui Wang,Xiao Yang,Yan Li,Gencheng Han,Yuxian He,Xiaojun Zhou,Shusheng Geng,Xiaoli Sheng,Shibo Jiang,Shihui Sun,Cheng-Feng Qin,Yusen Zhou +31 more
TL;DR: A mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia is developed, and a panel of adaptive mutations potentially associated with the increased virulence are revealed.
Journal ArticleDOI
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury.
Penghui Yang,Hongjing Gu,Zhongpeng Zhao,Wei Wang,Bin Cao,Chengcai Lai,Xiaolan Yang,Liangyan Zhang,Yueqiang Duan,Shaogeng Zhang,Weiwen Chen,Wenbo Zhen,Maosheng Cai,Josef M. Penninger,Chengyu Jiang,Xiliang Wang +15 more
TL;DR: It is demonstrated that ACE2 plays a critical role in influenza A (H7N9) virus-induced acute lung injury, and suggested that might be a useful potential therapeutic target for future influenza A(H7n9) outbreaks.
Journal ArticleDOI
Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus
Hongjing Gu,Zhengde Xie,Tieling Li,Shaogeng Zhang,Chengcai Lai,Ping Zhu,Keyu Wang,Lina Han,Yueqiang Duan,Zhongpeng Zhao,Xiaolan Yang,Li Xing,Peirui Zhang,Zhouhai Wang,Ruisheng Li,Jane J. Yu,Xiliang Wang,Penghui Yang +17 more
TL;DR: It is demonstrated that angiotensin-converting enzyme-2 (ACE2) protected against severe lung injury induced by RSV infection in an experimental mouse model and in pediatric patients, and suggested that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.
Posted ContentDOI
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2
Shihui Sun,Hongjing Gu,Lei Cao,Qi Chen,Guan Yang,Ruiting Li,Hang Fan,Qing Ye,Yong-Qiang Deng,Xiaopeng Song,Yini Qi,Min Li,Jun Lan,Rui Feng,Lei Wang,Yifei Zhang,Chao Zhou,Lingna Zhao,Yuehong Chen,Meng Shen,Yujun Cui,Xiao Yang,Xinquan Wang,Hui Wang,Xiangxi Wang,Cheng-Feng Qin +25 more
TL;DR: A mouse adapted SARS-CoV-2 strain that harbored three amino acid substitutions in the RBD of S protein showed 100% mortality in aged, male BALB/c mice is generated and the molecular mechanism for the rapid adaption and evolution of Sars-Cov-2 in mice is unveiled.