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Yan Guo
Researcher at Academy of Military Medical Sciences
Publications - 58
Citations - 3503
Yan Guo is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Virus & Lung injury. The author has an hindex of 27, co-authored 58 publications receiving 2409 citations.
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Journal ArticleDOI
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy.
Hongjing Gu,Qi Chen,Guan Yang,Lei He,Hang Fan,Yong Qiang Deng,Yanxiao Wang,Yue Teng,Zhongpeng Zhao,Yujun Cui,Li Yuchang,Xiaofeng Li,Jiangfan Li,Na Na Zhang,Xiaolan Yang,Shaolong Chen,Yan Guo,Guangyu Zhao,Xiliang Wang,De Yan Luo,Hui Wang,Xiao Yang,Yan Li,Gencheng Han,Yuxian He,Xiaojun Zhou,Shusheng Geng,Xiaoli Sheng,Shibo Jiang,Shihui Sun,Cheng-Feng Qin,Yusen Zhou +31 more
TL;DR: A mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia is developed, and a panel of adaptive mutations potentially associated with the increased virulence are revealed.
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A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
Shi Hui Sun,Qi Chen,Hong Jing Gu,Guan Yang,Yan Xiao Wang,Xing Yao Huang,Su Su Liu,Na Na Zhang,Xiaofeng Li,Rui Xiong,Yan Guo,Yong Qiang Deng,Weijin Huang,Quan Liu,Quan Ming Liu,Yue Lei Shen,Yong Zhou,Xiao Yang,Tong Yan Zhao,Chang Fa Fan,Yu Sen Zhou,Cheng-Feng Qin,You Chun Wang +22 more
TL;DR: This animal model, generated using CRISPR/Cas9 knock-in technology, provides a useful tool for studying SARS-CoV-2 transmission and pathogenesis, and evaluating COVID-19 vaccines and therapeutics.
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A Thermostable mRNA Vaccine against COVID-19.
Na Na Zhang,Xiaofeng Li,Yong Qiang Deng,Hui Zhao,Yi Jiao Huang,Guan Yang,Weijin Huang,Peng Gao,Chao Zhou,Rong Rong Zhang,Yan Guo,Shi Hui Sun,Hang Fan,Shu Long Zu,Qi Chen,Qi He,Tian Shu Cao,Xing Yao Huang,Hong Ying Qiu,Jian Hui Nie,Yuhang Jiang,Hua Yuan Yan,Qing Ye,Xia Zhong,Xia Lin Xue,Zhen Yu Zha,Dongsheng Zhou,Xiao Yang,You Chun Wang,Bo Ying,Cheng-Feng Qin +30 more
TL;DR: A lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (termed ARCoV) is developed and is currently being evaluated in phase 1 clinical trials.
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Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV
Yuting Jiang,Guangyu Zhao,Nianping Song,Pei Li,Yuehong Chen,Yan Guo,Junfeng Li,Lanying Du,Shibo Jiang,Shibo Jiang,Renfeng Guo,Shihui Sun,Yusen Zhou +12 more
TL;DR: The data indicate that dysregulated host immune responses contribute to the severe outcome of MERS; excessive complement activation, triggered by MERS-CoV infection, promote such dysregulation; and blockade of the C5a–C5aR axis lead to the decreased tissue damage induced by Mers-Cov infection, as manifested by reduced apoptosis and T cell regeneration in the spleen.
Journal ArticleDOI
Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model.
TL;DR: It is suggested that RBD, which can induce protective antibodies to SARS-CoV, may be further developed as a safe and effective SARS subunit vaccine.